263358-31-2

Upstream product

• 7693-46-1 4-Nitrophenyl chloroformate 
• 391610-40-5 6-(Benzofurazan-5-yl)-1,6-dihydro-2-methoxy-5-methoxycarbonyl-4-methyl-1-[(4-nitrophenyloxy)carbonyl]pyrimidine 
• 216310-91-7 4-benzo[1,2,5]oxadiazol-5-yl-2-methoxy-6-methyl-1,4-dihydro-pyrimidine-5-carboxylic acid methyl ester 
• 391610-53-0 6-(BENZOFURAZAN-5-YL)-1,6-DIHYDRO-2-OXO-5-METHOXYCARBONYL-4-BROMOMETHYL-1-[(4-NITROPHENYLOXY)CARBONYL]PYRIMIDINE 

Relevant academic research and scientific papers

Synthesis and evaluation of furo[3,4-d]pyrimidinones as selective α(1a)-adrenergic receptor antagonists

Furo[3,4-d]pyrimidinones were found to be metabolites of dihydropyrimidinones such as 1a-b that are subtype-selective antagonists of the α(1a)-adrenergic receptor. A versatile synthesis that provides access to furo[3,4-d]pyrimidinones in high yield and in enantiomerically pure forms is described along with structure-activity relationships in the series.

SELECTIVE MELANIN CONCENTRATING HORMONE-1 (MCH1) RECEPTOR ANTAGONISTS AND USES THEREOF

This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of modifying feeding behavior of a subject which comprises administering to the subject an amount of a compound of the invention effective to decrease the consumption of food by the subject. This invention further provides a method of treating a feeding disorder in a subject which comprises administering to the subject an amount of a compound of the invention effective to decrease the consumption of food by the subject. In an embodiment of the invention, the feeding disorder is bulimia, bulimia nervosa or obesity.