263387-25-3Relevant academic research and scientific papers
New hydrazones bearing thiazole scaffold: Synthesis, characterization, antimicrobial, and antioxidant investigation
Nastasa, Cristina,Tiperciuc, Br?ndusa,Duma, Mihaela,Benedec, Daniela,Oniga, Ovidiu
, p. 17325 - 17338 (2015)
New series of hydrazones 5-18 were synthesized, in good yields, by reacting 4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carbohydrazide with differently substituted benzaldehyde. The resulting compounds were characterized via elemental analysis, physico-chemical and spectral data. An antimicrobial screening was done, using Gram (+), Gram (-) bacteria and one fungal strain. Tested molecules displayed moderate-to-good growth inhibition activity. 2,2-Diphenyl-1-picrylhydrazide assay was used to test the antioxidant properties of the compounds. Monohydroxy (14-16), para-fluorine (13) and 2,4-dichlorine (17) derivatives exhibited better free-radical scavenging ability than the other investigated molecules.
