263400-88-0

Basic information

• Product Name: toluene-4-sulfonic acid 3-Methanesulfonyl-propyl ester
• Synonyms: toluene-4-sulfonic acid 3-Methanesulfonyl-propyl ester;3-(Methylsulfonyl)propyl 4-Methylbenzenesulfonate;ALG-1A78317;3-(Methylsulfonyl)propyl tosylate;toluene-4-sulfonic acid 3-Methanesulfonyl-propyl ester-3
• CAS NO: 263400-88-0
• Molecular Formula: C₁₁H₁₆O₅S₂
• Molecular Weight: 292.37174
• EINECS: -0
• Mol File: 263400-88-0.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 510.7±33.0 °C(Predicted)
• Appearance: /
• Density: 1.302±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: toluene-4-sulfonic acid 3-Methanesulfonyl-propyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: toluene-4-sulfonic acid 3-Methanesulfonyl-propyl ester(263400-88-0)
• EPA Substance Registry System: toluene-4-sulfonic acid 3-Methanesulfonyl-propyl ester(263400-88-0)

Safety Data

• Hazardous Substances Data: 263400-88-0(Hazardous Substances Data)

Usage

General Description

Toluene-4-sulfonic acid 3-Methanesulfonyl-propyl ester is a chemical compound commonly used as a reagent in organic synthesis and pharmaceutical manufacturing. It is a derivative of toluene-4-sulfonic acid, which is a strong acid commonly utilized in acidic catalysis and as a reagent for sulfonate ester formation. The methanesulfonyl-propyl ester group attached to the toluene-4-sulfonic acid moiety enhances its solubility and reactivity, making it an important intermediate in the production of various organic compounds and pharmaceuticals. Its versatile nature and high reactivity make it a valuable component in the synthesis of a wide range of chemical products.

Upstream product

• 505-10-2 3-(methylthio)-1-propanol 
• 98-59-9 p-toluenesulfonyl chloride 
• 2058-49-3 3-(methylsulfonyl)propan-1-ol 
• 187722-18-5 3-(methylthio)-1-propanol mono-p-toluenesulfonate 

Downstream Products

• 1000413-84-2 2',6'-dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-carbaldehyde 
• 1236765-43-7 2-{[3-(Methylsulfonyl)propyl]sulfanyl}-3-[4-(2,2,2-trifluoroethoxy)phenyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one 
• 1236766-18-9 3-[4-(Cyclopropylmethoxy)phenyl]-2-{[3-(methylsulfonyl)propyl]sulfanyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one 
• 1236766-15-6 2-{[3-(methylsulfonyl)propyl]sulfanyl}-3-{4-[(2,2,2-trifluoroethoxy)methyl]phenyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one 
• 1236766-78-1 3-[4-(Cyclopropylmethoxy)phenyl]-2-{[3-(methylsulfonyl)propyl]sulfanyl}-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one 
• 1372195-69-1 2-bromo-5-(3-methanesulfonyl-propoxy)-1,3-dimethyl-benzene 
• 1093967-02-2 2-amino-5-(isopropylsulfonyl)-3-[3-(methylsulfonyl)propoxy]benzonitrile 
• 1179163-53-1 3-(3-(methylsulfonyl)propoxy)aniline 

Relevant articles and documents

SYNTHESIS OF 3-({5-CHLORO-1-[3-(METHYLSULFONYL)PROPYL]-1H-INDOL-2 YL} METHYL)-1-(2,2,2-TRIFLUOROETHYL)-1,3-DIHYDRO-2H-IMIDAZO[4,5-C]PYRIDIN-2-ONE

The present invention relates to a chemical synthesis route for preparing the RSV inhibiting compound 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-10 1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one, and to new compounds used as intermediate compounds in the multistep process.

SULFONAMIDES AS GPR40- AND GPR120-AGONISTS

The invention relates to compounds acting as agonists of G-protein coupled receptor 120 (GPR120) and/or 40 (GPR40), and having formula (I). Said compounds are useful in the treatment of diseases or disorders modulated by GPR120 and/or GPR40 such as diabet

GPR40 AGONISTS IN ANTI-DIABETIC DRUG COMBINATIONS

Disclosed are compositions comprising (a) a GPR40 agonist and (b) an SGLT2 inhibitor, and methods for treating of disorders that are affected by the modulation of the GPR40 receptor and SGLT2 transporter. Such GPR40 compounds are represented by Formula (I) as follows: wherein ring W, R1, R2, R3, R5, R6, A, and Z, are defined herein.