263404-04-2Relevant academic research and scientific papers
Desulfonylation of amides using tributyltin hydride, samarium diiodide or zinc/titanium tetrachloride. A comparison of methods
Knowles, Haydn S.,Parsons, Andrew F.,Pettifer, Robert M.,Rickling, Stéphane
, p. 979 - 988 (2007/10/03)
Deprotection of N-sulfonylated amides can be achieved by reaction with Bu3SnH, SmI2 or TiCl4/Zn. All three methods gave good yields (typically >60%) when using N-benzoyl or related amides while the corresponding N~acetyl derivatives proved to be inert to deprotection under the same reaction conditions. The mechanistic implications of this are discussed. (C) 2000 Elsevier Science Ltd.
