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263410-04-4

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263410-04-4 Usage

Chemical Class

Benzoic acid derivative

Functional Groups

BOC-protected amino group
Ethyl ether linker

Application Areas

Pharmaceutical chemistry
Medicinal chemistry

Utility

Synthesis of drugs and peptides
Building block for complex molecule synthesis

BOC-Protecting Group

Used to protect amine functionalities
Prevents unwanted reactions or side reactions

Flexibility in Modification

Structure allows for modification and functionalization
Enables creation of compounds with specific properties and activities

Potential

Drug development
Chemical synthesis

Check Digit Verification of cas no

The CAS Registry Mumber 263410-04-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,3,4,1 and 0 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 263410-04:
(8*2)+(7*6)+(6*3)+(5*4)+(4*1)+(3*0)+(2*0)+(1*4)=104
104 % 10 = 4
So 263410-04-4 is a valid CAS Registry Number.

263410-04-4Relevant articles and documents

Zn(OTf)2-catalyzed, microwave-promoted synthesis of 2-substituted 5-methyloxazoles from propargylic amides

Safrygin, Alexander,Dar'in, Dmitry,Lukin, Alexei,Bakholdina, Anna,Sapegin, Alexander,Krasavin, Mikhail

, p. 777 - 779 (2019/02/13)

The versatile conversion of propargylic amides to the respective 2-substituted 5-methyloxazoles was efficiently catalyzed by Zn(OTf)2 (5 mol%) under microwave irradiation in toluene. The method was applicable to a wide range of aliphatic, aroma

Compositions and methods for treating tuberculosis

-

, (2016/06/01)

The invention provides for the use of antimicrobial chemical entities based on a nitrothiazolide backbone that exhibit anti-mycobacteria activity, including the mycobacterium causing tuberculosis. Multiple compounds were synthesized and screened for anti-tuberculosis activity. Disclosed herein are a series of compounds with anti-tuberculosis activity, including six leads that completely inhibited bacterial growth at 5 micrograms per ml or less. Three of these compounds were tested to determine MIC and these ranged between 1 and 4 micrograms per ml against both drug susceptible Mycobacterium tuberculosis strains and strains that are multi-drug resistant (MDR) including XDR strains. The compounds developed are derived from parent compound nitazoxanide, which had no inhibitory activity in the stringent testing format used herein. The derivatives were synthesized using a di-nitro-thiophene or 4-Chloro-5-Nitro-thiazole scaffold and R groups connected via a peptide bond (NHCO) to cyclic compounds such as benzene, thiophene or furans. Many of these compounds have broad spectrum activity against Gram positive bacteria including Staphylococcus aureus (MRSA) and Staphylococcus epidermidis. Several of these lead compounds were not toxic for mice at 200 mg/Kg doses administered over a period of three days.

BROAD SPECTRUM BENZOTHIOPHENE-NITROTHIAZOLIDE AND OTHER ANTIMICROBIALS

-

Page/Page column 91-93; 109-110, (2010/10/03)

The invention provides novel antimicrobial chemical entities based on a nitrothiazolide backbone that exhibit antibacterial and antiparasitic action against a wide range of human pathogens. The new classes of compounds show extended action against Gram positive bacteria including MRSA drug resistant pathogens. In the Gram-positive organisms, they specifically target and functionally inhibit microbial attachment to surfaces and biofilm formation. In Gram-negative bacteria, including enteroaggregative E. coli strains, these compounds function as pilicides by inhibiting the assembly of pilin subunits into adhesive filaments. Several of these compounds show potent antimicrobial action against Gram positive bacteria, perhaps involving novel targets. Many of the benzothiophene derivatives exhibit antimicrobial activity in the low micrograms per ml range and in blocking biofilm formation in the nanomolar range; ranges considered are well within the range of utility as therapeutics.

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