26342-14-3Relevant academic research and scientific papers
A dual catalytic strategy for carbon-phosphorus cross-coupling via gold and photoredox catalysis
He, Ying,Wu, Hongmiao,Toste, F. Dean
, p. 1194 - 1198 (2015)
A new method for the P-arylation of aryldiazonium salts with H-phosphonates via dual gold and photoredox catalysis is described. The reaction proceeds smoothly at room temperature in the absence of base and/or additives, and offers an efficient approach t
Preparation method and application of antibacterial drugs
-
Paragraph 0019-0024, (2020/05/02)
The invention provides phosphite ester compounds with an antibacterial effect and represented by a general formula I, a preparation method of the compounds, an application of the compounds in antibacterial drugs and pharmaceutical compositions containing the compounds. The ten synthesized compounds are novel in structure, the antibacterial activity of the compounds is equivalent to or even superior to that of positive control clindamycin and ciprofloxacin, the antibacterial spectrum is wide, and the compounds 5 and 10 are particularly expected to be further developed into antibacterial activedrugs.
Photoinduced Transition-Metal-Free Cross-Coupling of Aryl Halides with H-Phosphonates
Zeng, Huiying,Dou, Qian,Li, Chao-Jun
supporting information, p. 1301 - 1305 (2019/02/19)
Photoinduced transition-metal- and photosensitizer-free cross-coupling of aryl halides (including Ar-Cl, Ar-Br, and Ar-I) with H-phosphonates (including dialkyl phosphonates and diarylphosphine oxides) is reported. Various functional groups were tolerated, including ester, methoxy, dimethoxy, alkyl, phenyl, trifluoromethyl, and heterocyclic compounds. This simple and green strategy provides a practical pathway to synthesize arylphosphine oxides.
Visible-Light photo-Arbuzov reaction of aryl bromides and trialkyl phosphites yielding aryl phosphonates
Shaikh, Rizwan S.,Düsel, Simon J.S.,K?nig, Burkhard
, p. 8410 - 8414 (2018/05/23)
Aryl phosphonates are functional groups frequently found in pharmaceutical and crop protection agents. For their synthesis via C?P bond formation typically transition-metal-catalyzed reactions are used. We report a visible-light photo-Arbuzov reaction as an efficient, mild, and metal-free alternative. Rhodamine 6G (Rh.6G) is used as the photocatalyst, generating aryl radicals under blue light. Coupling of the radicals with a wide range of trivalent phosphites gives aryl phosphonates in good to very good isolated yields. The mild reaction conditions allow the introduction of a phosphonate group into complex and sensitive pharmaceutically active molecules such as benzodiazepams and nicergoline by the activation of a carbon?halogen bond.
Copper-catalyzed coupling reaction of arylhydrazines and trialkylphosphites
Chen, Sheng-Yan,Zeng, Run-Sheng,Zou, Jian-Ping,Asekun, Olayinka Taiwo
, p. 1449 - 1453 (2014/03/21)
A novel CuO-catalyzed coupling reaction of arylhydrazines with trialkyl phosphites to afford arylphosphonates is described. The reaction proceeded at 80 C in air without external reductants, oxidants, and ligands.
