26346-85-0

Basic information

• Product Name: 2-BROMO-1-(2,4-DIMETHYLPHENYL)ETHAN-1-ONE
• Synonyms: 2,4-DIMETHYLPHENACYLBROMIDE;2-BROMO-2',4'-DIMETHYLACETOPHENONE;2-BROMO-1-(2,4-DIMETHYLPHENYL)ETHAN-1-ONE;AKOS BBS-00004045;2,4-Dimethylphenacyl bromide 97%;2-broMo-1-(2,4-diMethylphenyl)ethanone;2-Bromo-1-(2,4-dimethylphenyl)ethan-1-one, 4-(Bromoacetyl)-m-xylene;2,4-Dimethylphenacylbromide97%
• CAS NO: 26346-85-0
• Molecular Formula: C₁₀H₁₁BrO
• Molecular Weight: 227.1
• Mol File: 26346-85-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 44 °C
• Boiling Point: 281.2°C at 760 mmHg
• Flash Point: 64.3°C
• Appearance: /
• Density: 1.362g/cm³
• Vapor Pressure: 0.00362mmHg at 25°C
• Refractive Index: 1.557
• CAS DataBase Reference: 2-BROMO-1-(2,4-DIMETHYLPHENYL)ETHAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-1-(2,4-DIMETHYLPHENYL)ETHAN-1-ONE(26346-85-0)
• EPA Substance Registry System: 2-BROMO-1-(2,4-DIMETHYLPHENYL)ETHAN-1-ONE(26346-85-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 26346-85-0(Hazardous Substances Data)

Usage

General Description

2-BROMO-1-(2,4-DIMETHYLPHENYL)ETHAN-1-ONE is a chemical compound with the molecular formula C10H11BrO. It is a white to off-white solid with a molecular weight of 231.1 g/mol. 2-BROMO-1-(2,4-DIMETHYLPHENYL)ETHAN-1-ONE is used in the synthesis of various pharmaceuticals and agrochemicals. It is also a versatile intermediate in the production of fine chemicals and organic compounds. 2-BROMO-1-(2,4-DIMETHYLPHENYL)ETHAN-1-ONE has potential applications in the fields of medicine, agriculture, and industrial chemistry due to its unique chemical properties. However, it is important to handle and use this compound with proper safety precautions, as it can be hazardous if not handled correctly.

InChI:InChI=1/C10H11BrO/c1-7-3-4-9(8(2)5-7)10(12)6-11/h3-5H,6H2,1-2H3

Upstream product

• 861555-96-6 1-(bromoethynyl)-2,4-dimethylbenzene 
• 598-21-0 2-Bromoacetyl bromide 
• 108-38-3 m-xylene 
• 7664-93-9 sulfuric acid 
• 64-19-7 acetic acid 
• 89-74-7 2,4-dimethylacetophenone. 

Downstream Products

• 101446-58-6 (5-chloro-benzofuran-2-yl)-(2,4-dimethyl-phenyl)-ketone 
• 14866-57-0 2,2,2-tribromo-1-(2,4-dimethylphenyl)ethanone 
• 801983-70-0 N-(2,4-Dimethylphenacyl)cyclopropylamin 
• 78394-78-2 1-[2-(2,4-Dimethyl-phenyl)-2-oxo-ethyl]-2,5-dimethyl-4-phenyl-pyridinium; bromide 
• 103793-29-9 1-methyl-3-[2-(2,4-dimethylphenyl)-2-oxoethyl]-1H-imidazolium bromide 
• 247225-31-6 4-(2,4-dimethyl-phenyl)thiazol-2-ylamine 
• 1134986-57-4 C₁₁H₁₂N₂O 
• 111184-18-0 1-Methyl-3-(2',4'-dimethylphenacyl)perimidinium Bromide 
• 94639-56-2 2-[2-(2,4-Dimethyl-phenyl)-2-oxo-ethylsulfanyl]-4-furan-2-yl-5,6,7,8-tetrahydro-quinoline-3-carbonitrile 
• 94639-37-9 (3-Amino-4-furan-2-yl-5,6,7,8-tetrahydro-thieno[2,3-b]quinolin-2-yl)-(2,4-dimethyl-phenyl)-methanone 

Relevant articles and documents

Discovery of novel potent GPR40 agonists containing imidazo[1,2-a]pyridine core as antidiabetic agents

Free fatty acid receptor 1 (FFA1 or GPR40) has been studied for many years as a target for the treatment of type 2 diabetes mellitus. In order to increase potency and reduce hepatotoxicity, a series of novel compounds containing imidazo[1,2-a]pyridine sca

Synthesis and antimicrobial activity evaluation of new dithiocarbamate derivatives bearing thiazole/benzothiazole rings

The synthesis of 2-(substituted phenyl)-2-oxoethyl 4-(pyrimidin-2-yl)piperazin-1-carbodithiodate (A1-A24) derivatives and 2-(4-substituted thiazol-2-ylamino)-2-oxoethyl 4-(pyrimidin-2-yl)piperazin-1-carbodithiodate (B1-B14) derivatives was undertaken starting from the potassium salt of 4-(2-pyrimidinyl)piperazine dithiocarbamate. The structures of the obtained compounds were elucidated by1H NMR,13C NMR, MS spectral data, and elemental analysis. The antimicrobial activity of the thirty eight newly synthesized compounds were tested against 12 microorganism strains using the microdilution technique. Compounds 2-(4-ethoxycarbonylthiazol-2-ylamino)-2-oxoethyl 4-(pyrimidin-2-yl)piperazin-1-carbodithiodate (B12), 2-(3-fluorophenyl)-2-oxoethyl 4-(pyrimidin-2-yl)piperazin-1-carbodithiodate (A18) and 2-(3,4-difluorophenyl)-2-oxoethyl 4-(pyrimidin-2-yl)piperazin-1-carbodithiodate (A21) were determined to possess high antimicrobial activity.

Synthesis and biological evaluation of N-(4-phenylthiazol-2-yl)cinnamamide derivatives as novel potential anti-tumor agents

In this study, a series of novel N-(4-phenylthiazol-2-yl)cinnamamide derivatives (7a-8n) were synthesized and evaluated for their anti-proliferative activities in vitro by MTT assay and a possible antitumor mechanism was also explored. SAR analysis showed that steric effects played an important role on the anti-tumor activity. The most potent analogue 8f showed excellent inhibitions on the K562, Bel7402, A549 and Jurkat cells ranging from sub-micromolar to nanomolar concentration. Compound 8f inhibited Jurkat cells with an IC50 value of 0.035 μM with no apparent toxicity in different non-cancerous cells. Furthermore, it was suggested that the possible mechanism of 8f might be associated with inducing cancer cell apoptosis following flow cytometer analysis and Hoechst 33358 staining assays.