2637-44-7

Upstream product

• 2002-24-6 2-amino-ethanol hydrochloride 
• 133641-28-8 Z-Trp-O-COO-isoBu 
• 141-43-5 ethanolamine 
• 7432-21-5 N-carbobenzyloxy-L-tryptophane 
• 73-22-3 L-Tryptophan 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 143868-61-5 Z-Trp-Aib-Trp-Glyol 
• 143868-67-1 H-Phe-Aib-Trp-Aib-Trp-Glyol 
• 143868-68-2 Z-Phe-Aib-Trp-Aib-Trp-Glyol 
• 143868-54-6 Z-Trp-Aib-Trp-Aib-Trp-Glyol 
• 143868-65-9 H-Trp-Aib-Phe-Aib-Trp-Aib-Trp-Glyol 
• 143868-66-0 Z-Trp-Aib-Phe-Aib-Trp-Aib-Trp-Glyol 
• 143868-49-9 Z-Trp-Aib-Trp-Aib-Trp-Aib-Trp-Glyol 

Relevant academic research and scientific papers

C ring may be dispensable for β-carboline: Design, synthesis, and bioactivities evaluation of tryptophan analog derivatives based on the biosynthesis of β-carboline alkaloids

According to our previous work and the latest research on the biosynthesis of β-carboline, and using the reverse thinking strategy, tryptophan, the biosynthesis precursor of β-carboline alkaloids, and their derivatives were synthesized, and their biological activities and structure-activity relationships were studied. This bioassay showed that these compounds exhibited good inhibitory activities against tobacco mosaic virus (TMV); especially (S)-2-amino-3-(1H-indol-3-yl)-N-octylpropanamide (4) (63.3 ± 2.1%, 67.1 ± 1.9%, 68.7 ± 1.3%, and 64.5 ± 3.1%, 500 μg/mL) exhibited the best antiviral activity both in vitro and in vivo. Compound 4 was chosen for the field trials and the acute oral toxicity test, the results showed that the compound exhibited good anti-TMV activity in the field and low acute oral toxicity. We also found that these compounds showed antifungal activities and insecticidal activities.

Tryptophan derivative, preparing method and application in preventing and treating plant viruses, killing bacteria and killing insects

The invention relates to a tryptophan derivative (I), a preparing method of the tryptophan derivative (I), and application of the tryptophan derivative (I) in preventing and treating plant viruses, killing bacteria and killing insects. The formula of the tryptophan derivative (I) is shown in the description, and the meanings of all groups in the formula are shown in the description. The tryptophan derivative expresses especially excellent plant virus resisting activity, and also has broad-spectrum bactericidal activity and insecticidal activity.

Changes in Conformation and Antimicrobial Properties Caused by Replacement of D-Amino Acids with α-Aminoisobutyric Acid in the Gramicidin Backbone: Synthesis and Circular Dichroic Studies

In an attempt to mimic the stable helical structures of proteins with possible pore-forming ability in membranes, the linear gramicidin backbone has been changed by inserting achiral α-aminoisobutyric acids (Aib) in place of all of the alternatively seque

Amino alcohols as C-Terminal Protecting Groups in Peptide Synthesis

The synthesis of peptides using amino alcohols as C-terminal protecting groups is described.C-Terminal protection of amino acid could be accomplished by reduction of the terminal carboxyl group to a hydroxymethyl group, and regeneration of the carboxyl group could be achieved by Jones' oxidation.This method was applied to the formation of di- and tripeptides.