263719-76-2

Usage

Uses

Used in Pharmaceutical Industry:
Tert-butyl 1,2,5-thiadiazolidine-2-carboxylate1,1-dioxide is used as a reactant for the preparation of thiadiazolidine dioxides from amino acids and chlorosulfonyl isocyanate. These thiadiazolidine dioxides are of significant interest in the pharmaceutical industry due to their potential applications as therapeutic agents. They may exhibit various biological activities, such as anti-inflammatory, analgesic, or antimicrobial properties, which can be beneficial in the development of new drugs.
Used in Chemical Synthesis:
In the field of organic chemistry, tert-butyl 1,2,5-thiadiazolidine-2-carboxylate1,1-dioxide serves as an important intermediate for the synthesis of various complex organic molecules. Its unique structure allows for a wide range of chemical reactions, making it a versatile building block for the creation of novel compounds with potential applications in various industries, such as agriculture, materials science, and pharmaceuticals.
Used in Research and Development:
Tert-butyl 1,2,5-thiadiazolidine-2-carboxylate1,1-dioxide is also utilized in research and development laboratories for the exploration of new synthetic routes and the investigation of its chemical properties. tert-butyl 1,2,5-thiadiazolidine-2-carboxylate1,1-dioxide can provide valuable insights into the reactivity of thiadiazolidine dioxides and contribute to the advancement of chemical knowledge in this area.

Upstream product

• 182925-49-1 N¹-BOC,N³-(2-chloroethyl) sulfamide 
• 57260-73-8 N-BOC-1,2-diaminoethane 
• 263719-64-8 tert-butyl N-(2-hydroxyethyl)sulfamoylcarbamate 
• 174466-48-9 methyl -glycinate 
• 147000-89-3 N-tert-butyloxycarbonylsulfamoyl chloride 

Downstream Products

• 1193318-32-9 C₃₀H₃₁N₃O₅S₂ 
• 1261242-40-3 C₂₄H₂₆FN₇O₄S₂ 
• 1341126-82-6 tert-butyl 5-[(1-(4-methoxybenzyl)-1H-1,2,3-triazol-4-yl)methyl]-1,2,5-thiadiazolidine-2-carboxylate 1,1-dioxide 
• 1341126-81-5 tert-butyl 5-[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]-1,2,5-thiadiazolidine-2-carboxylate 1,1-dioxide 
• 1092980-92-1 C₁₃H₁₆FN₃O₆S 

Relevant academic research and scientific papers

SALT FORM AND CRYSTAL FORM OF 1,2,5-THIADIAZOLIDIN-1,1-DIOXIDE, PREPARATION METHOD THEREOF AND INTERMEDIATE

The present invention discloses a salt form, crystal form and intermediate of the compound 1, and preparation method thereof.

ANTI-ENTEROVIRUS 71 THIADIAZOLIDINE DERIVATIVE

Disclosed is a novel anti-enterovirus 71 (EV71) 1,2,5-thiadiazolidine-1,1-dioxide derivative or a pharmaceutically acceptable salt thereof; and specifically, a compound represented by formula (II) or a pharmaceutically acceptable salt thereof.

Potent inhibition of Norwalk virus by cyclic sulfamide derivatives

A new class of compounds that exhibit anti-norovirus activity in a cell-based system and embody in their structure a cyclosulfamide scaffold has been identified. The structure of the initial hit (compound 2a, ED50 4 μM, TD50 50 μM) has been prospected by exploiting multiple points of diversity and generating appropriate structure-activity relationships.

Synthesis of new 6-(4-Fluorophenyl)-5-(2-substituted pyrimidin-4-yl) imidazo[2,1-b] thiazole derivatives and their antiproliferative activity against melanoma cell line

Synthesis of a new series of pyrimidinyl-imidazo[2,1-b]thiazole derivatives is described. Their antiproliferative activity against A375 human melanoma cell line was tested and the effect of substituents on the pyrimidinyl ring side chain was investigated.

Novel lβ-methylcarbapenems having cyclic sulfonamide moieties: Synthesis and evaluation of in-vitro biological activity - Part II

The synthesis of a new series of 1β-methylcarbapenems having cyclic sulfonamide moieties is described. Their in-vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of a substituent on the pyrroli

Synthesis and antibacterial activities of novel oxazolidinones having cyclic sulfonamide moieties

The synthesis of a new series of oxazolidinones having cyclic sulfonamide moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the oxazolidinone

Novel lβ-methylcarbapenems having cyclic sulfonamide moieties: Synthesis and evaluation of in vitro antibacterial activity

The synthesis of a new series of 1β-methylcarbapenems having cyclic sulfonamide moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituent on the pyrrolidi

Synthesis of 1,2,5-thiadiazolidines 1,1-dioxides (Cyclosulfamides) starting from amino acids and chlorosulfonyl isocyanate

We report here a practical access to a series of five-membered cyclosulfamides (1,2,5-thiadiazolidines 1,1-dioxides) N2 substituted by the BOC group. These compounds are synthesized starting from chlorosulfonyl isocyanate and nitrogen mustards or amino acids. The derivatization of amino acids can lead to an alkyl group on C-4 with a well-defined configuration; in this case the N5 position was protected by a benzyl group. These compounds are valuable tools for asymmetric synthesis. (C) 2000 Elsevier Science Ltd.