26378-53-0

Basic information

• Product Name: 2-(2-CHLOROPHENOXY)ETHYLAMINE
• Synonyms: 1-ETHANAMINE, 2-(2-CHLOROPHENOXY)-;2-(2-CHLOROPHENOXY)ETHYLAMINE;2-(2-CHLOROPHENOXY)-1-ETHANAMINE;2-CHLOROPHENOXY-2-ETHANEAMINE;AURORA KA-7595;BUTTPARK 97\57-77;RARECHEM AL BW 0341;[2-(2-chlorophenoxy)ethyl]amine hydrochloride
• CAS NO: 26378-53-0
• Molecular Formula: C₈H₁₀ClNO
• Molecular Weight: 171.62
• EINECS: 26378-53-0
• Mol File: 26378-53-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 39-40°C
• Boiling Point: 115-117°C 5mm
• Flash Point: 150-153°C/18mm
• Appearance: /
• Density: 1.178 g/cm³
• Vapor Pressure: 0.00879mmHg at 25°C
• Refractive Index: 1.544
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 8.32±0.10(Predicted)
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 2-(2-CHLOROPHENOXY)ETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-CHLOROPHENOXY)ETHYLAMINE(26378-53-0)
• EPA Substance Registry System: 2-(2-CHLOROPHENOXY)ETHYLAMINE(26378-53-0)

Safety Data

• Hazard Codes: Xi
• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 2735
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 26378-53-0(Hazardous Substances Data)

Usage

General Description

2-(2-chlorophenoxy)ethylamine is a chemical compound that consists of a chlorophenyl group attached to an ethylamine group. It is used in the synthesis of various pharmaceuticals and organic compounds due to its versatile reactivity and structure. This chemical has been studied for its potential applications in the pharmaceutical industry, particularly in the development of new medications for various medical conditions. It is important to handle this compound with caution and follow proper safety protocols, as it may pose hazards if not handled properly.

InChI:InChI=1/C8H10ClNO/c9-7-3-1-2-4-8(7)11-6-5-10/h1-4H,5-6,10H2

Upstream product

• 1448366-55-9 tert-butyl (2-(2-chlorophenoxy)ethyl)carbamate 
• 95-57-8 2-monochlorophenol 
• 66443-61-6 1-(2-azidoethoxy)-2-chlorobenzene 
• 727368-76-5 2-[2-(2-chloro-phenoxy)-ethyl]-isoindole-1,3-dione 
• 18800-26-5 1-(2-bromoethoxy)-2-chlorobenzene 

Downstream Products

• 69323-96-2 [2-(2-chloro-phenoxy)-ethyl]-(6-chloro-quinazolin-4-yl)-amine 
• 64502-63-2 1-[2-(2-Chloro-phenoxy)-ethylamino]-3-phenoxy-propan-2-ol 
• 76210-86-1 1-[2-(2-Chloro-phenoxy)-ethylamino]-3-(4-nitro-phenoxy)-propan-2-ol 
• 138803-34-6 1-[2-(2-Chloro-phenoxy)-ethylamino]-3-(6-chloro-pyridazin-3-yloxy)-propan-2-ol 
• 68250-99-7 3-[2-(2-chloro-phenoxy)-ethyl]-2-(2,4-dichloro-phenyl)-thiazolidin-4-one 
• 68250-72-6 3-[2-(2-chloro-phenoxy)-ethyl]-2-(4-methoxy-phenyl)-thiazolidin-4-one 
• 68250-62-4 3-[2-(2-chloro-phenoxy)-ethyl]-2-phenyl-thiazolidin-4-one 
• 68250-80-6 3-[2-(2-chloro-phenoxy)-ethyl]-2-(2-chloro-phenyl)-thiazolidin-4-one 
• 68306-60-5 3-[2-(2-chloro-phenoxy)-ethyl]-2-(4-chloro-phenyl)-thiazolidin-4-one 

Relevant articles and documents

Design, synthesis, crystal structure, and herbicidal activity of novel pyrrolidine-2,4-dione derivatives incorporating an alkyl ether pharmacophore with natural tetramic acids as lead compounds

In order to discover green herbicides with novel molecular scaffolds, natural tetramic acids were used as lead compounds to design and synthesize four pyrrolidine-2,4-dione derivatives incorporating a chainlike alkoxyalkyl moiety (4a-4d) and nineteen pyrrolidine-2,4-dione derivatives incorporating a substituted phenoxyethyl moiety (10a-10s)viasubstitution, acylation, cyclization, and acidification reactions. The synthesized target compounds were confirmed by FT-IR,1H NMR,13C NMR and HRMS spectral analyses. The single-crystal structure of compound10awas analyzed by X-ray diffraction, which revealed that the 1-hydroxyethylidene group links the third position of the pyrrolidine heterocycle through a double bond with theZ-configuration. The herbicidal activity was evaluated using barnyard grass (Echinochloa crus-galli) and rape (Brassica campestris) as model plants by a Petri dish culture method. Most target compounds were found to possess moderate to good inhibitory activities against the plant growth at 100 μg mL?1. Among them, the compounds10qand10nshowed the highest herbicidal activities against the roots of barnyard grass and rape seedlings with the corresponding inhibition rates of 65.6% and 84.0%, respectively. This result indicated that pyrrolidine-2,4-dione derivatives incorporating a substituted phenoxyethyl moiety are worthy of further structural optimization.

Novel synthetic strategy of N-arylated heterocycles via sequential palladium-catalyzed intra- and inter-arylamination reactions

The use of an in situ generated Pd(0) catalyst associated to N,N′-bis(2,6-diisopropylphenyl)dihydroimidazol-2-ylidene (SIPr) as a ligand and t-BuONa as the base for sequential intra- followed by intermolecular aryl animation is described. The method has been applied to the synthesis of N-arylated five-, six- and seven-membered nitrogen heterocycles.

Phenoxypropanol connected with phenylpiperazine and phenoxyalkylamine terminal in its side chain

The invention disclosed some 1,4-dihydropiridine derivative chemically have pharmacologically with adrenoceptor blocking and calcium channel blocker is now emerging. The compound of 1,4-dihydropiridine derivative wherein has the formula I, wherein R selected from four group as follow whetherin R present R1 selected from halogen(X), hydrogen(H), saturated C1-C6 alkyl chain, saturated C1-C6 alkyoxyl chain, R2 selected from R3 selected from halogen(X), hydrogen(H), saturated C1-C6 alkyl chain, saturated C1-C6 alkyoxyl chain, and O—(C1-C3)—CF3.