264147-90-2

Upstream product

• 264147-87-7 (E)-1-benzyloxy-3-(R)-[2-(1,3-dimethyl-2-oxo-4-(R)-5-(R)-[octahydro-2λ⁵-benzo[1.3.2]diazaphosphol-2-yl)vinyl]aziridine]-2-(R)-carboxylic acid tert-butyl ester 

Downstream Products

• 264147-99-1 1-benzyloxy-3-(tert-butyl-dimethyl-silanyloxymethyl)-aziridine-2-carboxylic acid tert-butyl ester 
• 370064-95-2 1-benzyloxy-3-(S)-(pyridin-3-yloxymethyl)aziridine-2-(R)-carboxylic acid tert-butyl ester 
• 370064-70-3 1-benzyloxy-3-(S)-(4-phenoxyphenoxymethyl)aziridine-2-(R)-carboxylic acid tert-butyl ester 
• 370064-96-3 [1-benzyloxy-3-(S)-(pyridin-3-yloxymethyl)aziridine-2-(R)-yl]methanol 
• 370064-97-4 3-[1-benzyloxy-3-(R)-(tert-butyldimethylsilanyloxymethyl)aziridin-2-(S)-ylmethoxy]pyridine 
• 370064-71-4 [1-benzyloxy-3-(S)-(4-phenoxyphenoxymethyl)aziridine-2-(R)-yl]methanol 
• 370065-20-6 (2R,3S)-1-Benzyloxy-3-(4-phenoxy-phenoxymethyl)-aziridine-2-carboxylic acid 
• 370064-72-5 1-benzyloxy-2-(R)-(tert-butyldimethylsilanyloxymethyl)-3-(S)-(4-phenoxyphenoxymethyl)aziridine 
• 370065-21-7 1-benzyloxy-3-(S)-(4-phenoxyphenoxymethyl)aziridine-2-(R)-carboxylic acid benzyloxyamide 
• 264147-94-6 Acetic acid (2R,3S)-1-benzyloxy-3-(tert-butyl-dimethyl-silanyloxymethyl)-aziridin-2-ylmethyl ester 
• 264148-07-4 C₁₄H₁₄Cl₃NO₅ 
• 264147-93-5 [(2R,3S)-1-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxymethyl)-aziridin-2-yl]-methanol 
• 264148-05-2 (S)-4-Benzyloxyamino-dihydro-furan-2-one 
• 264148-01-8 (2S,3R)-3-Benzyloxyamino-2-chloro-4-hydroxy-butyric acid tert-butyl ester 

Relevant academic research and scientific papers

Design and synthesis of MMP inhibitors using N-arylsulfonylaziridine hydroxamic acids as constrained scaffolds

The synthesis of cis- and trans-aziridine hydroxamic acid derivatives as MMP inhibitors is described using enantio- and diastereoselective methods for the formation of trisubstituted aziridines. Their preliminary inhibitory activity is reported and discus

The synthesis of enantiomerically pure disubstituted aziridines and N- alkoxy aziridines

The addition of a chloroallyl phosphonamide anion to oximes has allowed the preparation of a variety of cis-disubstituted N-alkoxy aziridines in enantiomerically pure form. Oxidative cleavage of the chiral auxiliary followed by derivatization of the products has allowed the preparation of enantiopure N-alkoxy aziridines. (C) 2000 Elsevier Science Ltd.