26417-26-5Relevant academic research and scientific papers
Palladium- and nickel-catalyzed cross-couplings of unsaturated halides bearing relatively acidic protons with organozinc reagents
Manolikakes, Georg,Munoz Hernandez, Carmen,Schade, Matthias A.,Metzger, Albrecht,Knochel, Paul
supporting information; experimental part, p. 8422 - 8436 (2009/04/11)
(Chemical Equation Presented) A wide range of polyfunctional aryl, heteroaryl, alkyl, and benzylic zinc reagents were coupled with unsaturated aryl halides bearing an acidic NH or OH proton, using Pd(OAc)2 (1 mol %) and S-Phos (2 mol %) as catalyst without the need of protecting groups. A similar nickel-catalyzed reaction is described. The relative kinetic basicity of organozinc compounds as well as their stability toward acidic protons is also described.
