264197-95-7

Upstream product

• 264197-90-2 (4S,5R)-4-Benzyloxycarbonylamino-1-tert-butoxycarbonylamino-8-nonene-5-ol 
• 264197-89-9 ⁽⁴⁾-4-Benzyloxycarbonylamino-1-tert-butoxycarbonylamino-8-nonene-5-one 
• 294664-65-6 2-benzyloxycarbonylamino-5-tert-butoxycarbonylamino-pentanethioic acid S-pyridin-2-yl ester 
• 7733-29-1 Z-Orn(Boc)-OH 

Downstream Products

• 264198-06-3 (2S,2'R,5'R,1''S)-3-[5'-(1''-Benzyloxycarbonylamino-4''-[N²''',N³'''-bis(tert-butoxycarbonyl)guanidino]butyl)tetrahydrofuran-2'-carbamoyl]-2-benzyloxycarbonylamino methyl propionate 
• 264197-99-1 (2S,2'R,5'R,1''S)-3-[5'-(1''-Benzyloxycarbonylamino-4''-[N²''',N³'''-bis(tert-butoxycarbonyl)guanidino]butyl)tetrahydrofuran-2'-carbamoyl]-2-butylsulfonylamino methyl propionate 
• 264198-00-7 (2S,2'S,5'R,1''S)-3-[5'-(1''-Benzyloxycarbonylamino-4''-[N²''',N³'''-bis(tert-butoxycarbonyl)guanidino]butyl)tetrahydrofuran-2'-carbamoyl]-2-butylsulfonylamino methyl propionate 
• 264198-05-2 (2S,2'R,5'R,1''S)-3-[5'-(1''-Benzyloxycarbonylamino-4''-tert-butoxycarbonylaminobutyl)tetrahydrofuran-2'-carbamoyl]-2-benzyloxycarbonylamino methyl propionate 
• 264197-98-0 (2S,2'RS,5'R,1''S)-3-[5'-(1''-Benzyloxycarbonylamino-4''-tert-butoxycarbonylaminobutyl)tetrahydrofuran-2'-carbamoyl]-2-butylsulfonylamino methyl propionate 
• 264197-96-8 (2RS,5R,1'S)-5-(1'-Benzyloxycarbonylamino-4'-tert-butoxycarbonylaminobutyl)tetrahydrofuran-2-carboxylic acid 
• 264197-97-9 [(S)-4-Benzyloxycarbonylamino-4-((R)-5-formyl-tetrahydro-furan-2-yl)-butyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis and biological evaluation of integrin antagonists containing trans- and cis-2,5-disubstituted THF rings

The synthesis of a series of RGD mimetics is described. All compounds consist of a central 2,5-disubstituted tetrahydrofuran core, a variable linker to a guanidino group, and a β-amino alanine unit to mimic the carboxylic acid. Three types of linkers were