264264-27-9

Upstream product

• 264264-28-0 1,1-dimethylethyl-7-{[(trifluoromethyl)sulfonyl]oxy}-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate 
• 149354-02-9 1,1-dimethylethyl 7-cyano-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate 
• 149354-10-9 3-(tert-butyloxycarbonyl)-7-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepine 
• 149354-01-8 2,3,4,5-tetrahydro-1H-benzo[d]azepine-7-carbonitrile 
• 215790-29-7 trans-2-(1-(4-(N-tert-butoxycarbonyl)amino)cyclohexyl)acetaldehyde 
• 50351-80-9 7-methoxy-2,3,4,5-tetrahydro-1H-benz[d]azepine 
• 36133-00-3 2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol 
• 264264-24-6 {4-[2-(7-cyano-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-ethyl]-cyclohexyl}-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Novel 2,3,4,5-tetrahydro-1H-3-benzazepines with high affinity and selectivity for the dopamine D3 receptor

Starting from the dopamine D3 receptor antagonist SB-277011 1, a series of 2,3,4,5-tetrahydro-1H-3-benzazepines has been identified with high affinity for the dopamine D3 receptor and selectivity over the D2 receptor. The 3-acetamido-2-fluorocinnamide derivative 20 gave high D3 receptor affinity (pK(i) 8.4) with 130-fold selectivity over the D2 receptor. (C) 2000 Elsevier Science Ltd.