36133-00-3Relevant academic research and scientific papers
TETRAHYDRO-BENZOAZEPINE GLYCOSIDASE INHIBITORS
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Page/Page column 136, (2020/03/15)
Compounds of formula (I') wherein A, R1, R2, T1, T2, T3, T4, L, W, Z, R''', m and n have the meaning according to the claims can be employed, inter alia, for the treatment of tauopathies and Alzheimer's disease.
Tetrahydro-3-benzazepines with fluorinated side chains as NMDA and σ1 receptor antagonists: Synthesis, receptor affinity, selectivity and antiallodynic activity
Thum, Simone,Schepmann, Dirk,Ayet, Eva,Pujol, Marta,Nieto, Francisco R.,Ametamey, Simon M.,Wünsch, Bernhard
supporting information, p. 47 - 62 (2019/05/27)
The class of tetrahydro-1H-3-benzazepines was systematically modified in 1-, 3- and 7-position. In particular, a F-atom was introduced in β- or γ-position of the 4-phenylbutyl side chain in 3-position. Ligands with the F-atom in γ-position possess higher
Synthesis and biological evaluation of N-alkylated 8-oxybenz[c]azepine derivatives as selective PPARδ agonists
Luckhurst, Christopher A.,Ratcliffe, Marianne,Stein, Linda,Furber, Mark,Botterell, Sara,Laughton, David,Tomlinson, Wendy,Weaver, Richard,Chohan, Kamaldeep,Walding, Andrew
scheme or table, p. 531 - 536 (2011/02/27)
We describe the discovery of small molecule benzazepine derivatives as agonists of human peroxisome proliferator-activated receptor δ (PPARδ) that displayed excellent selectivity over the PPARα and PPARγ subtypes. Compound 8 displayed good PK in the rat a
COMPOUNDS HAVING AFFINITY FOR THE DOPAMINE D3 RECEPTOR AND USES THEREOF IN MEDICINE
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Page/Page column 22, (2010/02/15)
Compounds of formula (I) or a salt thereof are disclosed, wherein A, m R1, R2, R3, q, W1, W2, R4 and R5 are as defined in the description. Processes for preparation and uses of the compounds in medicine, for example for the treatment of schizophrenia or drug dependency, are also disclosed.
DOPAMINE RECEPTOR MODULATORS AS ANTIPSYCHOTIC AGENTS
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Page/Page column 25, (2010/02/07)
The invention provides compounds of formula (I):wherein A and B represent the groups -(CH2)m- and -(CH2)n-respectively; R1 represents hydrogen or C1-6alkyl; R2 represents hydroge
Novel 2,3,4,5-tetrahydro-1H-3-benzazepines with high affinity and selectivity for the dopamine D3 receptor
Austin, Nigel E.,Avenell, Kim Y.,Boyfield, Izzy,Branch, Clive L.,Hadley, Michael S.,Jeffrey, Phillip,Johnson, Christopher N.,Macdonald, Gregor J.,Nash, David J.,Riley, Graham J.,Smith, Alexander B.,Stemp, Geoffrey,Thewlis, Kevin M.,Vong, Antonio K. K.,Wood, Martyn
, p. 2553 - 2555 (2007/10/03)
Starting from the dopamine D3 receptor antagonist SB-277011 1, a series of 2,3,4,5-tetrahydro-1H-3-benzazepines has been identified with high affinity for the dopamine D3 receptor and selectivity over the D2 receptor. The 3-acetamido-2-fluorocinnamide derivative 20 gave high D3 receptor affinity (pK(i) 8.4) with 130-fold selectivity over the D2 receptor. (C) 2000 Elsevier Science Ltd.
2-pyrrolidinones, pharmaceutical compositions containing these compounds and processes for preparing them
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, (2008/06/13)
The invention relates to cyclic imino derivatives of general formula wherein A, B, E, X2 to X5 and Y are defined as in claim 1, the stereoisomers, tautomers, mixtures and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, preferably aggregation-inhibiting effects, pharmaceutical compositions which contain these compounds and processes for preparing them.
Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines
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, (2008/06/13)
Compounds of the general formula: STR1 and pharmaceutical acceptable salts thereof wherein R is H, lower alkyl, lower alkenyl, lower aralkenyl, cycloalkyl-alkyl, propargyl, lower aralkyl, hydroxyalkyl and esters thereof, heterocyclic, heterocyclic-alkyl,
