264279-01-8

Upstream product

• 149846-93-5 1-phenyl-4,4,4-trifluorobut-2-yn-1-ol 
• 100-52-7 benzaldehyde 

Downstream Products

• 264279-06-3 1-phenyl-2-(2,2,2-trifluoroethylidene)-3-decyn-1-ol 
• 264279-05-2 (Z)-1,4-diphenyl-2-(2,2,2-trifluoroethylene)-3-butyn-1-ol 
• 264279-08-5 1-phenyl-4-(4-methoxyphenyl)-2-(2,2,2-trifluoroethylidene)-3-butyn-1-ol 

Relevant academic research and scientific papers

Iron-Catalyzed Thiocyclization for the Synthesis of Trifluoro-methylated Benzothiophenes by C-H Functionalization of Aryl Disulfides

An iron-catalyzed thiocyclization of propynols with aryl disulfides has been developed for the synthesis of trifluoromethylated benzothiophenes. The one-pot tandem reaction involves Meyer-Schuster -rearrangement of propynols and radical cyclization through C-H functionalization of aryl disulfides. A variety of 2-trifluoroacyl benzothiophenes were prepared in moderate to good yields with good functional-group tolerance.

Synthesis of 3-Trifluoroethylfurans by Palladium-Catalyzed Cyclization-Isomerization of (Z)-2-Alkynyl-3-trifluoromethyl Allylic Alcohols

Hydroiodonation of trifluoromethyl propargylic alcohols 1 regio- and stereoselectively produce (Z)-2-iodo-3-trifluoromethyl allylic alcohols 2. (Z)-2-Alkynyl-3-trifluoromethyl allylic alcohols 5, available through Pd(PPh3)4-mediated coupling of 2 and terminal alkynes 4, cyclize and subsequently isomerize to 3-trifluoroethylfurans 6 upon catalysis under PdCl2(CH3CN)2 in THF at 5-10°C.