26429-96-9Relevant articles and documents
Trifluoromethylation of Unactivated Alkenes with Me3SiCF3 and N-Iodosuccinimide
Yang, Xinkan,Tsui, Gavin Chit
supporting information, p. 1521 - 1525 (2019/03/07)
A novel approach to the trifluoromethylation of unactivated alkenes is presented. This reaction is promoted by N-iodosuccinimide (NIS) under visible light irradiation without the need for photocatalysts. The mild conditions allow the direct synthesis of u
Phospholane-catalyzed wittig reaction
Werner, Thomas,Hoffmann, Marcel,Deshmukh, Sunetra
, p. 3286 - 3295 (2015/05/20)
We identified 2-phenylisophosphindoline 2-oxide as a suitable and potentially tunable catalyst for the catalytic Wittig reaction of aldehydes with activated organohalides. This catalyst was obtained by a straightforward two-step synthesis. Trimethoxysilane proved to be an efficient reducing agent for the in situ generation and regeneration of the catalyst from the corresponding phosphane oxide. Sodium carbonate was identified as a suitable base for the transformation. It is noteworthy that the particle size of the sodium carbonate had a tremendous effect on the outcome of the reaction. Under the optimized reaction conditions, 23 aldehydes were converted into the corresponding alkenes in high isolated yields of up to 88%. Moreover, an asymmetric catalytic Wittig reaction was performed for the desymmetrization of a prochiral diketone.
First Microwave-Assisted Catalytic Wittig Reaction
Werner, Thomas,Hoffmann, Marcel,Deshmukh, Sunetra
supporting information, p. 6873 - 6876 (2016/02/19)
We introduce a novel catalytic Wittig reaction based on an inexpensive and readily available phosphane oxide as a precatalyst. The performance of the reaction under microwave irradiation led to significantly improved yields and reaction rates relative to those obtained under conventional heating. Moreover, herein we enclose the first example of the asymmetric catalytic Wittig reaction based on a chiral phosphane as the catalyst.
