26431-52-7Relevant academic research and scientific papers
HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME
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Paragraph 00181, (2015/01/16)
Disclosed are compounds of formula (I): or a pharmaceutically acceptable salt thereof; wherein Y, Ra, Ra', Rc, Rf, X2, Rd, Rd', Re, Re', m, and G have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry, useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular and neurodegenerative diseases or disorders.
The regio- and stereoselective addition of carbon nucleophiles to trifluoromethyl phenylsulfanyl acetylene: A novel and expeditious approach to 3-trifluoromethyl furans
Jiang, Biao,Zhang, Fangjiang,Xiong, Wennan
, p. 665 - 667 (2007/10/03)
A convenient generation of trifluoromethyl phenylsulfanyl acetylene was realized from 2-bromo-1-phenylsulfanyl-3,3,3-trifluoropropene. The reagent was reacted with carbanions to give (1E,3E)-2-trifluoromethylbutadienyl phenyl sulfides regio- and stereoselectively, which underwent intramolecular cyclization in decalin at 190°C or in acetic acid with 1,4-benzoquinone and sodium acetate to afford 3-trifluoromethyl-substituted furans in high yields.
