26454-82-0

Usage

General Description

2-[2-(4-Bromophenyl)-2-Oxoethyl]Propanedinitrile, also known by its molecular formula C11H8BrNO2, is a chemical compound with a variety of potential applications. 2-[2-(4-Bromophenyl)-2-Oxoethyl]Propanedinitrile belongs to the ketone and nitrile chemical classes and is used in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It has a molecular weight of 274.09 g/mol and a melting point of 124-127°C. Its structural composition includes a 4-bromophenyl group attached to a double-bonded carbon, which then links to another carbon bonded to two nitrile groups. The compound's precise role in chemical processes and products may vary, but its reactive and stable structural features make it valuable in the synthesis of a variety of important chemical compounds.

Upstream product

• 99-73-0 para-bromophenacyl bromide 
• 109-77-3 malononitrile 

Downstream Products

• 748810-19-7 2-amino-5-(4-bromo-phenyl)-1-phenyl-1H-pyrrole-3-carbonitrile 
• 26454-86-4 2-amino-5-(4-bromophenyl)furan-3-carbonitrile 
• 1240948-94-0 5-(4-bromophenyl)-2-(methylsulfanyl)-1H-pyrrole-3-carbonitrile 

Relevant academic research and scientific papers

Visible-light-accelerated pd-catalyzed cascade addition/ cyclization of arylboronic acids to γ- And β-ketodinitriles for the construction of 3-cyanopyridines and 3-cyanopyrrole analogues

The one-pot synthetic strategies for 2,4,6-triarylnicotinonitriles and 2,5-diaryl-1H-pyrrole-3-carbonitriles have been accomplished via a Pd-catalyzed coupling of arylboronic acid with 2-(3-oxo-1,3-diarylpropyl)malononitrile and 2-(2-oxo-2- arylethyl)malo

One-Step, Effective, and Cascade Syntheses of Highly Functionalized Cyclopentenes with High Diastereoselectivity

Tetrabutylammonium fluoride works as an effective organocatalyst for the cycloaddition between phenacylmalononitriles and electron-deficient olefins (having substituent groups of NO2, CHO, and COR), providing a facile synthetic route to versatile multifunctionalized cyclopentenes having an allylic quaternary carbon center bearing both cyano and carboxamide groups with high yields and high diastereoselectivity. Preliminary studies reveal that these functionalized cyclopentenes are convenient precursors for making α-cyano-functionalized cyclopentadienone oximes.

Synthesis and biological evaluation of new tacrine analogues under microwave irradiation

Efficient routes to various kinds of heterocycles incorporating the p-halophenyl moiety have been synthesized. Different pyrrole derivatives have been synthesized, as well, by Thorpe–Ziegler cyclization. Therefore, we synthesized different analogues of tacrine by Friedl?nder reaction of o-amino nitriles (pyrazolo, furano and pyrrolo) with different cycloalkanones. The use of microwave irradiation leads to shorter production times and high product conversion. These synthesized compounds were biologically evaluated by Ellman’s test on acetylcholinesterase inhibition.

Regioselective alkylation of isopropylidene- and cyclohexylidenepropanedinitrile with phenacyl bromides

Alkylation of isopropylidene- and cyclohexylidenepropanedinitrile with phenacyl bromides gave 2,2-bis(2-aryl-2-oxoethyl)propanedinitriles. Direct alkylation of propanedinitrile with phenacyl bromides afforded only 2-(2-aryl-2-oxoethyl)propanedinitriles.

Synthesis of New Pyrrolo[2, 3-b]pyridines as a Potent Inhibitor of Tumour Necrosis Factor Alpha

The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines tumor necrosis factor α (TNF-α) and 1L-1β. Accordingly, new pyrrolo[2,3]pyridine derivatives 5 a-d were prepared from 2-amino-3-cyanopyrroles 3 a-d via the intermediate