26454-86-4

Basic information

• Product Name: 2-AMino-5-(4-broMophenyl)furan-3-carbonitrile
• Synonyms: 2-AMino-5-(4-broMophenyl)furan-3-carbonitrile;2-amino-5-(4-bromophenyl)-3-Furancarbonitrile
• CAS NO: 26454-86-4
• Molecular Formula: C₁₁H₇BrN₂O
• Molecular Weight: 263.09008
• Mol File: 26454-86-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 229-230 °C(Solv: ethanol (64-17-5))
• Boiling Point: 425.1±45.0 °C(Predicted)
• Appearance: /
• Density: 1.65±0.1 g/cm3(Predicted)
• PKA: -1.95±0.10(Predicted)
• CAS DataBase Reference: 2-AMino-5-(4-broMophenyl)furan-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMino-5-(4-broMophenyl)furan-3-carbonitrile(26454-86-4)
• EPA Substance Registry System: 2-AMino-5-(4-broMophenyl)furan-3-carbonitrile(26454-86-4)

Safety Data

• Hazardous Substances Data: 26454-86-4(Hazardous Substances Data)

Usage

General Description

2-Amino-5-(4-bromophenyl)furan-3-carbonitrile is a chemical compound with the molecular formula C12H8BrN3O. It is a nitrile derivative of furan, containing a 4-bromophenyl group and an amino group. 2-Amino-5-(4-bromophenyl)furan-3-carbonitrile has potential applications in pharmaceutical research and organic synthesis. It may exhibit biological activity and could be used as a building block for the synthesis of novel compounds with potential therapeutic properties. Its specific properties and potential uses would require further investigation and testing in laboratory experiments.

Upstream product

• 99-73-0 para-bromophenacyl bromide 
• 109-77-3 malononitrile 
• 26454-82-0 2,2-bis[2-(4-chlorophenyl)-2-oxoethyl]propanedinitrile 

Downstream Products

• 887592-53-2 6-(4-bromophenyl)-4-chlorofuro[2,3-d]pyrimidine 

Relevant articles and documents

Synthesis and biological evaluation of new tacrine analogues under microwave irradiation

Efficient routes to various kinds of heterocycles incorporating the p-halophenyl moiety have been synthesized. Different pyrrole derivatives have been synthesized, as well, by Thorpe–Ziegler cyclization. Therefore, we synthesized different analogues of tacrine by Friedl?nder reaction of o-amino nitriles (pyrazolo, furano and pyrrolo) with different cycloalkanones. The use of microwave irradiation leads to shorter production times and high product conversion. These synthesized compounds were biologically evaluated by Ellman’s test on acetylcholinesterase inhibition.

One-pot synthesis of substituted 2-amino-3-furonitriles

Solvent-free reaction of substituted a-haloketones with malononitrile in the presence of diethylamine provides an efficient one-pot synthesis of 2-amino-5-aryl (alkyl)-3-furonitriles in high yield.