26462-76-0

Upstream product

• 13835-32-0 (2R)-2-[(1R)-4-methylcyclohex-3-en-1-yl]propyl 3,5-dinitrobenzoate 
• 13835-75-1 (2R)-2-[(1R)-4-methylcyclohex-3-en-1-yl]propan-1-ol 
• 26462-75-9 Toluene-4-sulfonic acid (R)-2-((R)-4-methyl-cyclohex-3-enyl)-propyl ester 
• 143-33-9 sodium cyanide 

Downstream Products

• 26462-77-1 (S)-2-Methyl-6-((R)-4-methyl-cyclohex-3-enyl)-heptan-4-one 
• 26568-68-3 (+)-(2R)-(4-Methyl-3-cyclohexen-(1R)-yl)-6-methylheptan-4-on 
• 26575-87-1 (+)-epijuvabione 
• 26091-09-8 (+)-Epitodomatuic acid 
• 17904-27-7 (+)-(4R)-[(S)-1,5-dimethyl-3-oxohexyl]cyclohex-1-enecarboxylic acid methyl ester 
• 26462-78-2 (R)-4-((S)-1,5-Dimethyl-3-oxo-hexyl)-cyclohex-1-enecarbaldehyde 

Relevant academic research and scientific papers

Asymmetric Hydrocyanation of Alkenes without HCN

A general and efficient rhodium-catalyzed asymmetric cyanide-free hydrocyanation of alkenes has been developed. Based on the asymmetric hydroformylation/condensation/aza-Cope elimination sequences, a broad scope of substrates including mono-substituted, 1,2-, and 1,1-disubstituted alkenes (involving natural product R- and S-limonene) were employed, and a series of valuable chiral nitriles are prepared with high yields (up to 95 %) and enantioselectivities (up to 98 % ee). Notably, the critical factor to achieve high enantioseletivies is the addition of catalytic amount of benzoic acid. This novel methodology provides an efficient and concise synthetic route to the intermediate of vildagliptin and anagliptin.