264620-41-9

Upstream product

• 3439-73-4 4-(2-chloroethoxy)benzophenone 
• 264620-31-7 methyl (1S,2R)-2-[4-(2-chloroethoxy)phenyl]-1,2-diphenylcyclopropane-1-carboxylate 
• 264620-35-1 (1S,2R)-2-[4-(2-chloroethoxy)phenyl]-1,2-diphenyl-1-(hydroxymethyl)-cyclopropane 
• 1137-42-4 4-Hydroxybenzophenone 
• 22979-35-7 Methyl phenyldiazoacetate 
• 264620-39-5 (1R,2S)-1-[4-(2-chloroethoxy)phenyl]-1,2-diphenyl-2-vinylcyclopropane 
• 264620-30-6 1-[4-(2-chloroethoxy)phenyl]-1-phenylethylene 

Relevant academic research and scientific papers

Stereoselectivity of methyl aryldiazoacetate cyclopropanations of 1,1-diarylethylene. Asymmetric synthesis of a cyclopropyl analogue of tamoxifen.

[formula: see text] Dirhodium tetrakis(S-(N-dodecylbenzenesulfonyl)prolinate) (Rh2(S-DOSP)4)-catalyzed decomposition of methyl phenyldiazoacetate in the presence of 1,1-diarylethylenes results in intermolecular cyclopropanation with high enantioselectivity (up to 99% ee) and moderate diastereoselectivity (up to 80% de). The reaction was applied to the asymmetric synthesis of a cyclopropyl analogue of tamoxifen.