3439-73-4

Usage

Uses

Used in Pharmaceutical Industry:
4-(2-Chloroethoxy)benzophenone is used as an intermediate compound for the synthesis of Tamoxifen and its derivatives. Tamoxifen is a selective estrogen receptor modulator (SERM) that is primarily utilized in the treatment of breast cancer. 4-(2-Chloroethoxy)benzophenone's role in the creation of these medications highlights its importance in the development of cancer treatments.

Upstream product

• 98-88-4 benzoyl chloride 
• 622-86-6 2-chloroethoxybenzene 
• 107-04-0 1-Bromo-2-chloroethane 
• 1137-42-4 4-Hydroxybenzophenone 
• 107-07-3 2-chloro-ethanol 
• 107-06-2 1,2-dichloro-ethane 

Downstream Products

• 97818-83-2 (Z)-1-<4-(2-chloroethoxy)phenyl>-1,2-diphenyl-1-butene 
• 264620-30-6 1-[4-(2-chloroethoxy)phenyl]-1-phenylethylene 
• 1449579-16-1 (Z)-1-[4-(2-chloroethoxy)phenyl]-1-(4-fluorophenyl)-2-phenylprop-1-ene 
• 1449579-15-0 (Z)-1-[4-(2-chloroethoxy)phenyl]-1,2-diphenyl-prop-1-ene 
• 1449579-22-9 (Z)-1-(2-{4-[2-(4-fluorophenyl)-1-phenyl-propenyl]-phenoxy}-ethyl)-4-methylpiperazine 
• 1449579-21-8 (Z)-1-(2-{4-[2-(4-fluorophenyl)-1-phenyl-propenyl]-phenoxy}-ethyl) piperazine 
• 1449579-20-7 (Z)-1-(2-{4-[2-(4-fluorophenyl)-1-phenyl-propenyl ]-phenoxy}-ethyl)piperidine 
• 1449579-19-4 (Z)-1-{2-[4-(1,2-diphenyl-propenyl)-phenoxy]-ethyl}-4-methylpiperazine 
• 1449579-18-3 (Z)-1-{2-[4-(1,2-diphenyl-propenyl)-phenoxy]-ethyl}piperazine 
• 1449579-17-2 (Z)-1-{2-[4-(1,2-diphenylpropenyl)-phenoxy]-ethyl}piperidine 
• 1276031-01-6 C₂₄H₂₃ClO₂ 
• 1276031-03-8 (Z)-2-(4-hydroxylphenyl)-1-[4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-1-phenylbut-1-ene 
• 1307381-01-6 C₂₉H₃₄N₂O₂ 
• 1276030-97-7 (Z)-2-(4-iodophenyl)-1-[4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-1-phenylbut-1-ene 

Relevant academic research and scientific papers

Calcium ion fluorescent probe based on aggregation-induced effect and preparation method and application thereof

The present invention proposes a soluble tetraphenylethylene-based fluorescent probe represented by a structure formula (I), wherein the soluble tetraphenylethylene-based fluorescent probe can performhigh-selectivity fluorescence detection on Ca, is not interfered by other metal ions, has advantages of wide pH value range, good water solubility and high sensitivity, can be used for the selective detection of Ca in environmental and biological samples, and has a certain application prospect in the diagnosis of Ca related diseases. The formula (I) is defined in the specification.

Highly selective catalytic Friedel-Crafts acylation and sulfonylation of activated aromatic compounds using indium metal

The Friedel-Crafts acylation of activated benzenes with various aromatic and aliphatic acid chlorides was studied in the presence of indium metal. The reaction was accomplished in high isolated yields under solvent or solvent-less conditions. The method is also applicable for preparing diaryl sulfones from aromatic compounds and aryl sulfonyl chlorides.

Stereoselectivity of methyl aryldiazoacetate cyclopropanations of 1,1-diarylethylene. Asymmetric synthesis of a cyclopropyl analogue of tamoxifen.

[formula: see text] Dirhodium tetrakis(S-(N-dodecylbenzenesulfonyl)prolinate) (Rh2(S-DOSP)4)-catalyzed decomposition of methyl phenyldiazoacetate in the presence of 1,1-diarylethylenes results in intermolecular cyclopropanation with high enantioselectivity (up to 99% ee) and moderate diastereoselectivity (up to 80% de). The reaction was applied to the asymmetric synthesis of a cyclopropyl analogue of tamoxifen.

Crossed Coupling of Functionalised Ketones by Low Valent Titanium (The McMurry Reaction): A New Stereoselective Synthesis of Tamoxifen

Low valent titanium-mediated crossed coupling of substitued benzophenones of the 4-XPhCOPh, where X = MeO, ClCH2CH2O, BrCH2CH2O, CF3C6H4O, HO, and Me2NCH2CH2O, with propiophenone affords the corresponding but-1-enes in high yield with a marked preponderance of the Z-isomer in most cases.Remarkably, when X = OH the E:Z ratio is 9:1.The value of this method is illustrated by simple syntheses of (Z)-1-phenyl>-1,2-diphenylbut-1-ene (Tamoxifen) a drug widely used in the treatment of eostrogen-dependent breast tumors.

Synthesis and pharmacology of basic sec, tert alcohols and derivatives (Japanese)

In order to investigate the relation between chemical structure and pharmacological properties, 68 new compounds belonging to amino alcohol derivatives were synthesized. One of them showed twice as potent an analgesic activity as barbipyrine, and five of them were found to be as effective as barbipyrine. Antispasmodic activity was recognized in the solution of these compounds at the concentration from 10-4 to 10-7 g/ml. Almost all the compounds were shown to have local anesthetic activity and the duration of the activity of several substances was more than 120 min. In general, the pharmacological activity decreased in the order of aminoolefins, urethans, amino alcohols, and alkamine esters.