264625-24-3

Upstream product

• 113557-37-2 2-(2-bromo-4,5-dimethoxyphenethyl)-7,8-dimethoxy-4-methylthio-1,2,3,4-tetrahydroisoquinolin-3-one 
• 74-88-4 methyl iodide 
• 86-51-1 2,3-dimethyoxybenzaldehyde 
• 113557-33-8 2-bromo-4,5-dimethoxy-N-(2,3-dimethoxybenzyl)phenethylamine 
• 63375-81-5 2-(2-bromo-4,5-dimethoxyphenylphenyl)ethan-1-amine 

Downstream Products

• 264625-27-6 7,8-dimethoxy-2-(3,4-dimethoxyphenethyl)-4-methyl-1,2,3,4-tetrahydroisoquinolin-3-one 

Relevant academic research and scientific papers

Convenient synthesis of 2,3,9,10-tetraoxygenated protoberberine alkaloids and their 13-methyl alkaloids

New and convenient synthesis of 2,3,9,10-tetraoxygenated protoberberine alkaloids and their 13-methyl alkaloids through the same intermediates was developed. Acylation of the brominated benzylphenethylamine (13) with α- chloro-α-(methylthio)acetyl chloride, followed by cyclization with stannic chloride, furnished the key intermediates 4-methylthio-3- phenethylisoquinolin-3-ones (14), which were methylated to provide their methyl derivatives (17). Both isoquinolin-3-ones (14, 17) were easily transformed into protoberberine alkaloids (16) and their 13-methyl alkaloids (21) in good yield.