26466-66-0Relevant academic research and scientific papers
Base-mediated 1,3-dipolar cycloaddition of pyridinium bromides with bromoallyl sulfones: a facile access to indolizine scaffolds
Ganga Reddy, Velma,Hari Krishna, Namballa,Jadala, Chetna,Kamal, Ahmed,Shankaraiah, Nagula
, p. 8694 - 8701 (2020)
An expedient and transition-metal-free synthetic strategy has been developed for the construction of substituted indolizines from a unique combination of pyridinium salts and 2-bromoallyl sulfones. This approach does not compromise with the diverse substitutions on both the pyridinium salts and 2-bromoallyl sulfones. Wide substrate scope, operational simplicity, milder reaction conditions and good to moderate yields are the merits associated with the current approach. Moreover, this method provides two products which are amenable for the generation of a library of key indolizine building blocks. This journal is
