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N-desmethylflunitrazepam, also known as norflunitrazepam, is a metabolite of the benzodiazepine drug flunitrazepam. It is formed in the liver through the demethylation process, where one methyl group is removed from the parent compound. As an active metabolite, it possesses sedative, hypnotic, and anxiolytic properties, although its potency is generally lower than that of flunitrazepam. N-desmethylflunitrazepam has a longer half-life than its parent drug, which contributes to its prolonged effects on the central nervous system. It is primarily used in forensic toxicology to detect the presence of flunitrazepam, as it can be found in blood and urine samples even after the parent drug has been metabolized and cleared from the body.

2648-00-2

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2648-00-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2648-00-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,6,4 and 8 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 2648-00:
(6*2)+(5*6)+(4*4)+(3*8)+(2*0)+(1*0)=82
82 % 10 = 2
So 2648-00-2 is a valid CAS Registry Number.
InChI:InChI=1/C15H11FN2O/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19)

2648-00-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-fluoro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one

1.2 Other means of identification

Product number -
Other names Ro 05-3061

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2648-00-2 SDS

2648-00-2Downstream Products

2648-00-2Relevant academic research and scientific papers

Structure-Activity Relationship Studies of Retro-1 Analogues against Shiga Toxin

Abdelkafi, Hajer,Michau, Aurélien,Pons, Valérie,Ngadjeua, Flora,Clerget, Alexandra,Ait Ouarab, Lilia,Buisson, David-Alexandre,Montoir, David,Caramelle, Lucie,Gillet, Daniel,Barbier, Julien,Cintrat, Jean-Christophe

, p. 8114 - 8133 (2020/09/21)

High-throughput screening has shown that Retro-1 inhibits ricin and Shiga toxins by diminishing their intracellular trafficking via the retrograde route, from early endosomes to the Golgi apparatus. To improve the activity of Retro-1, a structure-activity relationship (SAR) study was undertaken and yielded an analogue with a roughly 70-fold better half-maximal effective concentration (EC50) against Shiga toxin cytotoxicity measured in a cell protein synthesis assay.

Thermolysis and radiofluorination of diaryliodonium salts derived from anilines

Linstad, Ethan J.,Vāvere, Amy L.,Hu, Bao,Kempinger, Jayson J.,Snyder, Scott E.,DiMagno, Stephen G.

, p. 2246 - 2252 (2017/03/17)

Aniline-derived diaryliodonium salts were synthesized and functionalized in good to excellent yields by judicious utilization of electron-withdrawing protecting groups. This simple approach opens another route to radiolabeling amino arenes in relatively complex molecules, such as flutemetamol.

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