2648-58-0Relevant academic research and scientific papers
A Simple and Unambiguous Synthesis of α,α- and α,α'-Dihalogeno Ketones
Barluenga, Jose,Llavona, Lujan,Concellon, Jose M.,Yus, Miguel
, p. 297 - 300 (2007/10/02)
A convenient method for the unambiguous preparation of α,α'-dihalogeno ketones 3 from in situ-generated chloromethyllithium and α-chloro or α-bromo carboxylic acid esters 1 at -78 deg C, is described.The unambiguous prparation of α,α-dihalogeno ketones 7 by using in situ-generated dihalogenomethyllithium and carboxylic acid esters 5 at -78 deg C is also reported.
