26482-40-6Relevant academic research and scientific papers
Copper(i)-catalysed asymmetric allylic reductions with hydrosilanes
Thanh Nguyen,Thiel, Niklas O.,Teichert, Johannes F.
, p. 11686 - 11689 (2017)
A copper(i)-catalysed asymmetric allylic reduction enables a regio- and stereoselective transfer of a hydride nucleophile in an SN2′-fashion onto allylic bromides. This transformation represents a conceptually orthogonal approach to allylic substitution reactions with carbon nucleophiles. A copper(i) complex based upon a chiral N-heterocyclic carbene (NHC) ligand allows for stereoselectivity reaching 99% ee. The catalyst enables a stereoconvergent reaction irrespective of the double bond configuration of the starting materials.
