26485-81-4

Usage

InChI:InChI=1/C18H16N2O2/c1-13(2)16-17(21)19(14-9-5-3-6-10-14)20(18(16)22)15-11-7-4-8-12-15/h3-12H,1-2H3

Upstream product

• 2652-77-9 1,2-diphenylpyrazolidine-3,5-dione 
• 67-64-1 acetone 
• 367-57-7 1,1,1-Trifluoro-2,4-pentanedione 
• 122-66-7 diphenyl hydrazine 

Downstream Products

• 102181-60-2 4-tert-pentyl-1,2-diphenyl-pyrazolidine-3,5-dione 
• 568-74-1 4-tert-butyl-1,2-diphenyl-pyrazolidine-3,5-dione 
• 2361-29-7 4-(1-methyl-1-cyanoethyl)-1,2-diphenyl-3,5-pyrazolidinedione 

Relevant academic research and scientific papers

Functionalization of 1,2-diphenylpyrazolidine-3,5-dione with polyfluoroalkyl-containing 2- and 3-oxo esters

Fluorine-containing analogues of non-steroidal antiinflammatory drugs Tribuzone and Ketazone have been synthesized by reaction of 1,2-diphenylpyrazolidine-3,5-dione with polyfluoroalkyl-containing 3- and 2-oxo esters. Ethyl 3-(pyrazolidin-4-yl)-3-(polyfluoroalkyl)prop-2-enoates have been obtained as Knoevenagel reaction products from 3-oxo esters in the presence of l-proline. Unlike with 3-oxo esters, addition of ethyl 3,3,3-trifluoro-2-oxopropanoate under basic conditions afforded ethyl 2-(pyrazolidin-4-yl)-3,3,3-trifluoro-2-hydroxypropanoate or its salt without elimination of a water molecule.

Preparation and Evaluation of Electrophilic Derivatives of Phenylbutazone as Inhibitors of Prostaglandin-H Synthase

The chemical syntheses and biological evaluation of several potential irreversible inhibitors for prostaglandin (PGH) synthase are described.These inhibitors were modeled after the nonsteroidal antiinflammatory (NSAI) drug phenylbutazone(4-n-butyl-1,2-dip