26487-67-2

Usage

Uses

Used in Pharmaceutical Synthesis:
2-(Hexamethyleneimino)ethyl chloride hydrochloride is used as an intermediate in the synthesis of various pharmaceuticals for its ability to facilitate the creation of complex organic molecules.
Used in Specialty Chemicals Production:
2-(HEXAMETHYLENEIMINO)ETHYL CHLORIDE HYDROCHLORIDE is utilized in the production of specialty chemicals, where its unique properties contribute to the development of advanced materials.
Used in Organic Synthesis:
2-(Hexamethyleneimino)ethyl chloride hydrochloride is used as a reagent in organic synthesis, particularly for the preparation of quaternary ammonium compound derivatives, due to its water solubility and reactivity.
Used in Surfactant Production:
In the industry of surfactants, 2-(Hexamethyleneimino)ethyl chloride hydrochloride is used as a key component in the manufacturing process, contributing to the formation of effective surface-active agents.
Used in Antistatic Agent Manufacturing:
2-(HEXAMETHYLENEIMINO)ETHYL CHLORIDE HYDROCHLORIDE is employed in the production of antistatic agents, where its properties help in reducing the buildup of static electricity in various applications.
Used in Industrial Chemicals:
2-(Hexamethyleneimino)ethyl chloride hydrochloride is utilized in the broader scope of industrial chemical production, serving as a versatile building block for a range of chemical products.

InChI:InChI=1/C8H16ClN.ClH/c9-5-8-10-6-3-1-2-4-7-10;/h1-8H2;1H

Upstream product

• 20603-00-3 2-(hexamethyleneimino)ethanol 
• 2205-31-4 1-(2-chloroethyl)-1H-hexahydroazepine 
• 4614-98-6 caprolactam potassium salt 

Downstream Products

• 678-26-2 perfluoropentane 
• 355-42-0 tetradecafluorohexane 
• 96009-83-5 Perfluoro(N-ethylhexamethyleneimine) 
• 96009-89-1 1-(2-Chloro-1,1,2,2-tetrafluoro-ethyl)-2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-azepane 
• 90433-55-9 4-(2-Azepan-1-yl-ethoxy)-benzoic acid methyl ester 
• 645400-94-8 1-[4-(2-azepan-1-yl-ethoxy)-phenyl]-6-methoxy-1-methyl-2-phenyl-1,2,3,4-tetrahydro-isoquinoline 
• 82874-17-7 2-(2-perhydroazepin-1-ylethylthio)-5-(2-chlorophenyl)-7-chloro-3H-1,4-benzodiazepine fumarate 
• 223251-09-0 4-[2-(azepan-1-yl)ethoxy]benzaldehyde 
• 1175146-65-2 1-(2-azidoethyl)azepane 
• 1438272-55-9 1-{2-[2-(2-propyl)phenoxy]ethyl}azepane hydrochloride 

Relevant academic research and scientific papers

A N-(2-chloroethyl) hexamethylene imine hydrochloride synthetic method

The invention discloses a new synthetic method of N-(2-chloroethyl) hexamethyleneimine hydrochloride. The method comprises the following steps: by taking the caprolactam sylvite as a raw material, performing alkylation, reducing and salifying to obtain the N-(2-chloroethyl) hexamethyleneimine hydrochloride, wherein the total yield is greater than 71% and the product purity is greater than 98.5%. The method has the advantages that the final product N-(2-chloroethyl) hexamethyleneimine hydrochloride is obtained by directly performing alkylation on the caprolactam sylvite, performing reduction reaction on the sodium borohydride and salifying with the hydrogen chloride gas under the condition of taking the isopropanol as a solvent. The product has a high purity without refining.

Side chain impacts on pH- and thermo-responsiveness of tertiary amine functionalized polypeptides

The systemic investigation of the structural impacts of side chains on the pH- and thermo-responsiveness of tertiary amine functionalized poly(l-glutamate)s (TA-PGs) was carried out. The TA-PGs polymers were effectively synthesized by Cu(I)-catalyzed azide-alkyne cycloaddition click reaction of azido tertiary amines with poly(γ-propargyl-l-glutamate) (PPLG). Turbimetric measurements were performed to characterize the pH- and temperature-induced phase transition of TA-PGs in aqueous solution, which suggested a structural dependence of the properties on the N-substituted groups and the "linkers" between 1,2,3-triazole ring and the tertiary amine groups in the side chains. In detail, the pH responsive properties of TA-PGs were basically determined by the hydrophobicity of the N-substituted groups in the side chains and the pH transition point (pHt) decreased as the increasing hydrophobicity of the N-substituted groups, while the temperature-responsiveness of TA-PGs were affected by either the N-substituted groups or the "linkers." TA-PGs with a moderate N-substituted amine group (e.g., DEA, PR, and PD) or a branched "linker" (e.g., iso-propylene and 2-methylpropylene group) were more likely to express the LCST-type phase transition tuned by pH variation. These structure-property relationships revealed in this study would help to develop the applications of TA-PGs in smart drug delivery systems. Copyright