264883-40-1Relevant academic research and scientific papers
One-pot, two-step synthesis of unnatural α-amino acids involving the exhaustive aerobic oxidation of 1,2-diols
Inada, Haruki,Furukawa, Keisuke,Shibuya, Masatoshi,Yamamoto, Yoshihiko
supporting information, p. 15105 - 15108 (2019/12/26)
Herein, we report the nor-AZADO-catalyzed exhaustive aerobic oxidations of 1,2-diols to α-keto acids. Combining oxidation with transamination using dl-2-phenylglycine led to the synthesis of free α-amino acids (AAs) in one pot. This method enables the rapid and flexible preparation of a variety of valuable unnatural AAs, such as fluorescent AAs, photoactivatable AAs, and other functional AAs for bioorthogonal reactions.
A novel approach to γ-hydroxy-α,β-unsaturated compounds
Krawczyk, Henryk,Wasek, Katarzyna,Kedzia, Jacek
experimental part, p. 3299 - 3306 (2009/05/11)
A simple synthesis of (E)-alk-1-enyl mesylates from (E)-alk-1- enylphosphonates is reported. Construction of γ-hydroxy-α,β- unsaturated compounds was achieved by a two-step process involving dihydroxylation of the enol mesylates followed by HWE reaction of the resulting α-hydroxy aldehydes with activated methylphosphonates. Enantioselective synthesis of the title compounds is also reported.
