124888-60-4

Basic information

• Product Name: 4-phenylbutane-1,2-diol
• CAS NO: 124888-60-4
• Molecular Weight: 166.22
• Mol File: 124888-60-4.mol
• Article Data: 42

Chemical Properties

• CAS DataBase Reference: 4-phenylbutane-1,2-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-phenylbutane-1,2-diol(124888-60-4)
• EPA Substance Registry System: 4-phenylbutane-1,2-diol(124888-60-4)

Safety Data

• Hazardous Substances Data: 124888-60-4(Hazardous Substances Data)

Upstream product

• 19344-91-3 (2,3-diphenyl-isoxazolidin-5-yl)-methanol 
• 768-56-9 4-Phenylbut-1-ene 
• 85531-71-1 (3-benzyloxiran-2-yl)methanol 
• 104-53-0 3-phenyl-propionaldehyde 
• 2243-53-0 trans-styrylacetic acid 
• 64920-29-2 2-oxo-4-phenylbutanoic acid ethyl ester 
• 1192826-26-8 4-phenethyl-1,3-dioxolane 
• 134134-76-2 (4,4-difluorobut-3-en-1-yl)benzene 
• 93921-85-8 ethyl 2-hydroxy-4-phenylbutanoate 
• 201230-82-2 carbon monoxide 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 100-39-0 benzyl bromide 
• 1567840-67-8 2,2-di-tert-butyl-4-phenethyl-1,3,2-dioxasilolane 
• 1126-76-7 1,2-Epoxy-4-phenylbutane 

Downstream Products

• 124988-64-3 (S)-4-phenyl-1,2-butanediol 
• 61397-29-3 2-Bromomethyl-2-(2,4-dichloro-phenyl)-4-phenethyl-[1,3]dioxolane 
• 1192826-26-8 4-phenethyl-1,3-dioxolane 
• 1189195-95-6 C₁₂H₁₅NO₅S 
• 1300732-48-2 C₁₂H₁₇NO₂S 
• 1567840-67-8 2,2-di-tert-butyl-4-phenethyl-1,3,2-dioxasilolane 
• 19969-15-4 4-Phenyl-butan-diol-(1,2)-bis-phenyl-urethan 
• 264883-40-1 phenylethyl oxy-acetaldehyde 
• 710-11-2 2-oxo-4-phenylbutyric acid 
• 4263-93-8 2-hydroxy-4-phenylbutanoic acid 
• 1012-05-1 D,L-homophenylalanine 
• 82795-51-5 D-homophenylalanine 
• 96613-91-1 (R)-2-Acetamido-4-phenylbutansaeure 
• 943-73-7 D-homophenylalanine 

Relevant articles and documents

Lewis Base Catalyzed Dioxygenation of Olefins with Hypervalent Iodine Reagents

1,2-Diols are extremely useful building blocks in organic synthesis. Hypervalent iodine reagents are useful for the vicinal dihydroxylation of olefins to give 1,2-diols under metal-free conditions, but strongly acidic promoters are often required. Herein, we report a catalytic vicinal dioxygenation of olefins with hypervalent iodine reagents using Lewis bases as catalysts. The conditions are mild and compatible with various functional groups.

Direct Synthesis of Free α-Amino Acids by Telescoping Three-Step Process from 1,2-Diols

A practical telescoping three-step process for the syntheses of α-amino acids from the corresponding 1,2-diols has been developed. This process enables the direct synthesis of free α-amino acids without any protection/deprotection step. This method was also effective for the preparation of a 15N-labeled α-amino acid. 1,2-Diols bearing α,β-unsaturated ester moieties afforded bicyclic α-amino acids through intramolecular [3 + 2] cycloadditions. A preliminary study suggests that the resultant α-amino acids are resolvable by aminoacylases with almost complete selectivity.

Palladium-Catalyzed meta-C-H Olefination of Arene-Tethered Diols Directed by Well-Designed Pyrimidine-Based Group

The palladium-catalyzed meta-olefination of arene-tethered diols attached to a well-designed pyrimidine moiety is presented. Applications of the protocol are illustrated by the synthesis of various diol-based natural products, such as coumarins, phenylpropanoids, stilbenes, and chalcones. Advantages of this method are demonstrated through the easy removal of the template and a gram-scale olefination reaction. Finally, experimental verification, including 1H NMR, ESI-MS and IR, and DFT studies are undertaken to elucidate the mechanistic complexity.