264888-19-9

Usage

Uses

Used in Food Industry:
PHOSPHATE is used as a sequestrant, emulsifier, solubility enhancer, and buffer for improving the quality, taste, and shelf life of a variety of foods.
Used in Analytical Chemistry:
PHOSPHATE is used as an ion chromatography standard solution for calibration of ion chromatography and other analytical techniques.
Used in Pharmaceutical Applications:
Athletes often use phosphate supplementation to enhance their performance, but it should be monitored by a healthcare specialist to prevent potential health risks. Interactions between phosphate preparations and several over-the-counter and prescription drugs are known, which may lead to complications such as hypophosphataemia and hyperkalaemia if not managed properly.
Used in Dental Applications:
Excess phosphate can cause problems with the health of teeth and gums, as it can lead to the removal of calcium from the teeth, resulting in dental issues.

Veterinary Drugs and Treatments

Phosphate is useful in large volume parenteral fluids to correct or prevent hypophosphatemia when adequate oral phosphorous intake is not possible. Hypophosphatemia may cause hemolytic anemia, thrombocytopenia, neuromuscular and CNS disorders, bone and joint pain, and decompensation in patients with cirrhotic liver disease. There is some controversy whether “a low phos” indicates that treatment is necessary.

Upstream product

• 124-43-6 sodium pyrophosphate 
• 22638-09-1 amino-phosphonate 
• 25841-83-2 PN₆OH₉ 
• 65814-10-0 diimidotrimetaphosphate 
• 56537-13-4 trimetaphosphimate 
• 65814-09-7 imidotrimetaphosphate 
• 80-15-9 Cumene hydroperoxide 
• 5994-61-6 phosphonomethylimino-di-acetic acid 
• 13674-84-5 tris-(2-chloro, 1-methylethyl)-phosphate 
• 56-65-5 ATP 
• 58-64-0 adenosine 5'-diphosphate 

Downstream Products

• 156-62-7 calcium cyanamide 
• 12190-75-9 chloroamine 

Relevant academic research and scientific papers

Intrinsic Apyrase-Like Activity of Cerium-Based Metal–Organic Frameworks (MOFs): Dephosphorylation of Adenosine Tri- and Diphosphate

Apyrase is an important family of extracellular enzymes that catalyse the hydrolysis of high-energy phosphate bonds (HEPBs) in ATP and ADP, thereby modulating many physiological processes and driving life activities. Herein, we report an unexpected discovery that cerium-based metal–organic frameworks (Ce-MOFs) of UiO-66(Ce) have intrinsic apyrase-like activity for ATP/ADP-related physiological processes. The abundant CeIII/CeIV couple sites of Ce-MOFs endow them with the ability to selectively catalyse the hydrolysis of HEPBs of ATP and ADP under physiological conditions. Compared to natural enzymes, they could resist extreme pH and temperature, and present a broad range of working conditions. Based on this finding, a significant inhibitory effect on ADP-induced platelet aggregation was observed upon exposing the platelet-rich plasma (PRP) to the biomimetic UiO-66(Ce) films, prefiguring their wide application potentials in medicine and biotechnology.

Degradation of tri(2-chloroisopropyl) phosphate by the UV/H2O2 system: Kinetics, mechanisms and toxicity evaluation

A photodegradation technology based on the combination of ultraviolet radiation with H2O2 (UV/H2O2) for degrading tri(chloroisopropyl) phosphate (TCPP) was developed. In ultrapure water, a pseudo-first order reaction was observed, and the degradation rate constant reached 0.0035 min?1 (R2 = 0.9871) for 5 mg L?1 TCPP using 250 W UV light irradiation with 50 mg L?1 H2O2. In detail, the yield rates of Cl? and PO43? reached 0.19 mg L?1 and 0.58 mg L?1, respectively. The total organic carbon (TOC) removal rate was 43.02%. The pH value of the TCPP solution after the reaction was 3.46. The mass spectrometric detection data showed a partial transformation of TCPP into a series of hydroxylated and dechlorinated products. Based on the luminescent bacteria experimental data, the toxicity of TCPP products increased obviously as the reaction proceeded. In conclusion, degradation of high concentration TCPP in UV/H2O2 systems may result in more toxic substances, but its potential application for real wastewater is promising in the future after appropriate optimization, domestication and evaluation.

PROCESS FOR OXIDATION OF N-(PHOSPHONOMETHYL)IMINODIACETIC ACID

An oxidation catalyst is prepared by pyrolyzing a source of iron and a source of nitrogen on a carbon support. Preferably, a noble metal is deposited over the modified support which comprises iron and nitrogen bound to the carbon support. The catalyst is effective for oxidation reactions such as the oxidative cleavage of tertiary amines to produce secondary amines, especially the oxidation of N-(phosphonomethyl)iminodiacetic acid to N-(phosphonomethyl)-glycine.

Contributions to the Chemistry of Phosphorus. 237. On the Reaction of Diphosphane(4) with Peroxo Compounds: Formation of Phosphinophosphinic Acid, H2PPH(O)OH, and Bis(phosphino)phosphinic Acid, (H2P)2P(O)OH

Diphosphane(4) reacts with peroxo compounds such as hydrogen peroxide, tetraline hydroperoxide, trifluoroperoxyacetic acid, and cumene hydroperoxide (which is particularly suited for preparative work) at -30°Cto furnish phosphinophosphinic acid, H2PP(O)OH (1), as the primary prod uct. Compound 1 disproportionates to a major extent in statu nascendi togive phosphanes (above all PH3) and monophosphorus acids of various oxi dation states as well as some bis(phosphino)phosphinic acid, (H2P)2P(O)OH (2). The acids 1 and 2 can be trapped and stabilized as their triethylammonium salts. The structures of these salts have been determined by spectroscopic investigations.