26489-75-8Relevant articles and documents
ORGANIC COMPOUNDS
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, (2021/09/11)
Disclosed are TRPM8 modulators as defined by formula (I) for achieving a cooling effect on skin and mucousa.
Asymmetric Oxidative Coupling of Phenols and Hydroxycarbazoles
Kang, Houng,Lee, Young Eun,Reddy, Peddiahgari Vasu Govardhana,Dey, Sangeeta,Allen, Scott E.,Niederer, Kyle A.,Sung, Paul,Hewitt, Kirsten,Torruellas, Carilyn,Herling, Madison R.,Kozlowski, Marisa C.
, p. 5505 - 5508 (2017/10/25)
The first examples of asymmetric oxidative coupling of simple phenols and 2-hydroxycarbazoles are outlined. Generation of a more vanadium catalyst by ligand design and by addition of an exogenous Br?nsted or Lewis acid was found to be key to coupling the more oxidatively resistant phenols. The resultant vanadium complex is both more Lewis acidic and more strongly oxidizing. Good to excellent levels of enantioselectivity could be obtained, and simple trituration readily provided the products with ≥95% ee.
Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole
Chen, Wen,Yang, Xiao-Dong,Li, Yan,Yang, Li-Juan,Wang, Xue-Quan,Zhang, Gao-Lan,Zhang, Hong-Bin
, p. 4250 - 4255 (2011/07/29)
A series of novel hybrid compounds between dihydrobenzofuran and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that substitution of the imidazolyl-1-position with an electron-donating dihydrobenzofuran, and the imidazolyl-3-position with a naphthylacyl or electron-rich phenacyl group, were vital for modulating cytotoxic activity.