264907-93-9Relevant academic research and scientific papers
A novel class of apical sodium co-dependent bile acid transporter inhibitors: The 2,3-disubstituted-4-phenylquinolines
Tollefson, Michael B.,Vernier, William F.,Huang, Horng-Chih,Chen, Fang Ping,Reinhard, Emily J.,Beaudry, Judith,Keller, Bradley T.,Reitz, David B.
, p. 277 - 279 (2000)
A series of 2,3-disubstituted-4-phenylquinolines were prepared and were found to inhibit the apical sodium co-dependent bile acid transporter (ASBT). Alkyl and ester substitution at the 3-position showed comparable activities while substitution at the 2-position was much more sensitive to the nature of the substituent. The synthesis and in vitro potency data are presented for this novel class of compounds. (C) 2000 Elsevier Science Ltd. All rights reserved.
