264925-29-3Relevant academic research and scientific papers
Synthesis and biological activities of novel antiallergic agents with 5- lipoxygenase inhibiting action
Nakano, Hiroyuki,Inoue, Tsutomu,Kawasaki, Nobuhide,Miyataka, Hideki,Matsumoto, Hitoshi,Taguchi, Takeo,Inagaki, Naoki,Nagai, Hiroichi,Satoh, Toshio
, p. 373 - 380 (2007/10/03)
Novel benzimidazole derivatives were synthesized and their pharmacological activities were examined. These compounds showed a good suppressive action on histamine release from rat peritoneal mast cells produced by antigen-antibody reaction, an antagonistic action on guinea pig ileum contraction caused by histamine, an inhibitory action on 5-lipoxygenase in rat basophilic leukemia-1 (RBL-1) cells, and a preventive action on NADPH dependent lipid peroxidation induced by Fe3+-ADP in rat liver microsomes. In addition, 1-[2-[2-(4-Hydroxy-2,3,5-trimethylphenoxy)ethoxy]-ethyl]-2-(4- methyl-1-homopiperazino)-1H-benzimidazole difumarate (BOM1006) exhibited a dose dependent suppressive action on 48 h homologous passive cutaneous anaphylaxis (PCA) reaction in rats orally administered the drug. (C) 2000 Elsevier Science Ltd.
