213276-21-2Relevant academic research and scientific papers
Synthesis of trimethylhydroquinone derivatives as anti-allergic agents with anti-oxidative actions
Kawasaki, Nobuhide,Miyataka, Hideki,Nishiki, Mayumi,Matsumoto, Hitoshi,Inagaki, Naoki,Nagai, Hiroichi,Satoh, Toshio
, p. 177 - 181 (1999)
A novel series of trimethylhydroquinone derivatives was synthesized and evaluated for their anti-lipid peroxidation activity in rat liver microsomes, inhibition of rat basophilic leukemia-1 (RBL-1) cell 5-lipoxygenase and 48 h homologous passive cutaneous anaphylaxis (PCA) activity in rats, 4-[4-[4- (Diphenylmethyl)-1-piperazinyl]butoxy]-2,3,6-trimethylphenol (9c) exhibited the ability to inhibit Fe3+-ADP induced NADPH dependent lipid peroxidation (IC50=5.3x 10-7 M), 5-lipoxygenase ((IC50=3.5x10-7 M) and PCA reaction (57% inhibition at 100 mg/kg p.o.).
