445384-31-6

Upstream product

• 26495-19-2 β,β-dicyano-3,5-dimethoxystyrene 
• 488725-51-5 4-(3-cyano-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-2-ylsulfanyl)-3-oxo-butyric acid isopropyl ester 
• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 109-77-3 malononitrile 
• 41051-20-1 4-chloroacetoacetic acid isopropyl ester 
• 123413-84-3 2-thioxo-2,5,6,7,8,9-hexahydro-1H-cyclohepta[b]pyridine-3-carbonitrile 

Relevant academic research and scientific papers

4-(3-Cyanopyridin-2-ylthio)acetoacetates in synthesis of heterocycles

Substituted 2-ammo-4-aryl-3-cyano-5-oxo-5,6-dihydro-4H-pyrano[2,3-d] pyrido[3′,2′:4,5]thieno[3,2-b]pyridines were synthesized by the reactions of 4-hydroxy-1H-thieno[2,3-b;4,5-b]dipyridin-2-ones with arylidenemalononitriles or by the three-component reactions of hydroxythienodipyridinones with aldehydes and malononitrile in DMF in the presence of Methylamine. Methods for syntheses of substituted 3-alkoxycarbonyl-6-amino-4-aryl-2-(3-cyanopyridin-2-ylthiomethyl)-4H-pyrans were developed on the basis of the reactions of 4-(3-cyanopyridin-2-ylthio) acetoacetates and arylidenemalononitriles or aldehydes and malononitrile. Ethyl 4-(3-cyanopyridin-2-ylthio)acetoacetate and 4-methoxybenzyl- idenecyanothioacetamide were used for the synthesis of 6-(pyridin-2- ylthiomethyl)-3-cyanopyridine-2(1H)-thione.