265103-45-5

Upstream product

• 108865-98-1 α-Acetylamino-β,β-dimethyl-β-propiothiolactone 
• 57230-74-7 2-(4-aminophenylamino)-4,6-diamino-1,3,5-triazine 
• 57230-73-6 2-(4-acetylaminophenyl)-4,6-diamino-1,3,5-triazine 
• 122-80-5 N-acetyl-p-phenylenediamine 
• 52-66-4 DL-Penicillamin 

Relevant academic research and scientific papers

Synthesis, electrochemical, and spectroscopic studies of novel S-nitrosothiols

A series of S-nitrosothiol compounds, structurally related to the NO-donor S-nitroso-N-acetyl-D,L-penicillamine (SNAP) that contain amidin groups were synthesised by S-nitrosation of the corresponding thiols and characterised. The kinetics of decomposition were investigated and showed that the two adenine-based thionitrites exhibited an unusual stability in aqueous solution compared to SNAP, suggesting that these compounds may complex the traces of free copper ions present in solution, which is known to catalyze the decomposition of thionitrites. The electrochemical behaviour of these compounds and their nitric oxide-releasing potential were studied by means of cyclic voltammetry techniques on mercury and glassy carbon electrodes.

Synthesis and uptake of nitric oxide-releasing drugs by the P2 nucleoside transporter in trypanosoma equiperdum

A series of S-nitrosothiols, structurally related to the NO-donor S-nitroso-N-acetylpenicillamine, and of organic nitrate esters that contain amidine groups which specify a recognition via the trypanosomal purine transporter P2, were synthesized and tested for their ability to inhibit the uptake of [2-3H]adenosine on Trypanosoma equiperdum. (C) 2000 Elsevier Science Ltd. All rights reserved.