265114-54-3

Usage

Uses

Used in Anticancer Applications:
Telomostatin is used as an anticancer agent for its ability to inhibit telomerase activity selectively in cancer cells. By targeting telomerase, it prevents the elongation of telomeres, leading to cell cycle arrest and eventual cell death. This selective action makes it a potentially effective treatment against various types of cancer, including solid tumors and leukemia.
Used in Drug Delivery Systems:
To enhance the efficacy and bioavailability of telomostatin, it is often incorporated into drug delivery systems. These systems can include nanoparticles, liposomes, or other carriers that facilitate the transport of the compound to the target site, improving its therapeutic outcomes and reducing potential side effects. The use of drug delivery systems can also help to overcome resistance mechanisms in cancer cells, making telomostatin a more effective treatment option.

Upstream product

• 912656-63-4 C₃₀H₂₄N₈O₈S 
• 890403-75-5 (S)-2-[3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidin-4-yl]oxazole-4-carboxylic acid 
• 203456-93-3 (S)-methyl 2-[3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidin-4-yl]oxazole-4-carboxylate 
• 912656-41-8 (R)-methyl 2-(1-(tert-butoxycarbonylamino)-2-(tert-butylthio)ethyl)-5-methyloxazole-4-carboxylate 
• 912656-43-0 2-(1-tert-butoxycarbonylamino-2-tert-butylsulfanyl-ethyl)-5-methyl-oxazole-4-carboxylic acid 
• 912656-68-9 2',2'-dimethyl-4',5'-dihydro-[2,4']bioxazolyl-4,3'-dicarboxylic acid 4-benzyl ester 3'-tert-butyl ester 
• 912656-36-1 N-Boc-Cys(S-tBu)-Thr-OMe 
• 912656-53-2 2''',2'''-dimethyl-4''',5'''-dihydro-[2,4';2',4'';2'',4''']quateroxazole-4,3'''-dicarboxylic acid 3'''-tert-butyl ester 
• 912656-47-4 2''-(1-tert-butoxycarbonylamino-2-tert-butylsulfanyl-ethyl)-5',5''-dimethyl-[2,4';2',4'']teroxazole-4-carboxylic acid methyl ester 
• 912656-51-0 2''',2'''-dimethyl-4''',5'''-dihydro-[2,4';2',4'';2'',4''']quateroxazole-4,3'''-dicarboxylic acid 4-benzyl ester 3'''-tert-butyl ester 
• 912656-45-2 2-(1-{[2-(1-tert-butoxycarbonylamino-2-tert-butylsulfanyl-ethyl)-5-methyl-oxazole-4-carbonyl]-amino}-2-hydroxy-propyl)-oxazole-4-carboxylic acid methyl ester 
• 912656-49-6 (S)-4-[(S)-1-(4-Benzyloxycarbonyl-oxazol-2-yl)-2-hydroxy-ethylcarbamoyl]-2',2'-dimethyl-4',5'-dihydro-[2,4']bioxazolyl-3'-carboxylic acid tert-butyl ester 
• 912656-61-2 C₃₁H₂₈N₈O₉S 
• 912656-59-8 C₃₀H₂₆N₈O₈S 

Relevant academic research and scientific papers

Novel polyoxazole-based cyclopeptides from Streptomyces sp. Total synthesis of the cyclopeptide YM-216391 and synthetic studies towards telomestatin

A convergent, complementary, synthetic approach to the contiguously linked tris-oxazole units 10, 11 and 12 in telomestatin (1) and YM-216391 (2) is described. The route involves coupling reactions between oxazole 4-carboxylic acids, viz16a, 16c, 16d and

Total synthesis of (R)-telomestatin

We have achieved a total synthesis of telomestatin, and its absolute configuration was determined to be (R). Coupling of cysteine-containing trisoxazole amine and serine-containing trisoxazole carboxylic acid, followed by macrocyclization, provided a 24-m

PROCESS FOR PREPARING SUBSTANCE GM-95

A method of manufacturing substance GM-95 having general formula [I], comprising (a) deprotect ing a macrocyclic compound having general formula [II] (wherein, R1's are the same or different and each represents a lower alkyl group, and R2