26512-15-2

Upstream product

• 87-51-4 indole-3-acetic acid 
• 81127-33-5 (1R,4S,6R)-6-Ethyl-7-oxo-2-aza-bicyclo[2.2.2]octane-2-carboxylic acid benzyl ester 
• 81127-33-5 (1R,4S,6S)-6-Ethyl-7-oxo-2-aza-bicyclo[2.2.2]octane-2-carboxylic acid benzyl ester 
• 104-15-4 toluene-4-sulfonic acid 
• 81127-39-1 endo-7-ethyl-2-(3-indolylacetyl)-6,6-dimethoxy-2-azabicyclo<2.2.2>octane 
• 81127-37-9 (1R,4S,7R)-7-(2-Methanesulfonyloxy-ethyl)-6,6-dimethoxy-2-aza-bicyclo[2.2.2]octane-2-carboxylic acid benzyl ester 
• 81127-35-7 (1R,4S,7R)-7-Ethoxycarbonylmethyl-6,6-dimethoxy-2-aza-bicyclo[2.2.2]octane-2-carboxylic acid benzyl ester 
• 81127-34-6 (1R,4S,6R)-6-Ethoxycarbonylmethyl-7-oxo-2-aza-bicyclo[2.2.2]octane-2-carboxylic acid benzyl ester 
• 76525-55-8 benzyl 9-(2-ethylenedioxyethyl)-1,4-dioxa-7-azaspiro<4.5>decane-7-carboxylate 
• 81127-36-8 (1R,4S,7R)-7-(2-Hydroxy-ethyl)-6,6-dimethoxy-2-aza-bicyclo[2.2.2]octane-2-carboxylic acid benzyl ester 
• 26496-56-0 (1R,4S,7S)-7-Ethyl-2-(2-1H-indol-3-yl-acetyl)-2-aza-bicyclo[2.2.2]octan-6-one 
• 81127-38-0 (1R,4S,7S)-7-Ethyl-6,6-dimethoxy-2-aza-bicyclo[2.2.2]octane-2-carboxylic acid benzyl ester 
• 81127-22-2 ethyl 5-(2-ethylenedioxyethyl)-3-hydroxypiperidine-1-carboxylate 
• 81127-32-4 (1R,4S,7S)-7-Ethyl-2-aza-bicyclo[2.2.2]octan-6-one 

Downstream Products

• 481-87-8 (+/-)-ibogamine 
• 481-87-8 (+/-)-epiibogamine 
• 481-87-8 (+/-)-epi-ibogamine 
• 481-87-8 (+/-)-ibogamine 

Relevant academic research and scientific papers

Short and Stereoselective Synthesis of (+/-)-Ibogamine via a Vinylsulfone Intermediate, IV

Ibogamine (11b) was synthesized starting from the vinyl sulfone 3.Addition of organocuprate reagents to 3 furnished 2a-d with high stereoselectivity.Only products from the syn addition of the cuprate reagents could be detected.Functional group transformat

1,6-dihydro-3(2H)-pyridinones. X. 2-azabicyclooctane Ring Formation via Intramolecular Michael reaction: Total synthesis of (+/-)-Ibogamine and (+/-)-Epiibogamine

A new elaboration method for the 2-azabicyclooctane ring via an intramolecular Michael reaction has been developed and applied to the total synthesis of (+/-)-ibogamine (1) and (+/-)-epiibogamine (2).The unsaturated estert (9) derived from ethyl 1,