265137-13-1Relevant academic research and scientific papers
Recognition and inhibition of HIV integrase by a novel dinucleotide
Taktakishvili, Michael,Neamati, Nouri,Pommier, Yves,Nair, Vasu
, p. 249 - 251 (2000)
The viral enzyme, HIV integrase, is involved in the integration of viral DNA into host cell DNA. In the quest for a small nucleotide system with nuclease stability of the internucleotide phosphate bond and critical structural features for recognition and inhibition of HIV-1 integrase, we have discovered a conceptually novel dinucleotide, pIsodApdC, which is a potent inhibitor of this key viral enzyme. (C) 2000 Elsevier Science Ltd. All rights reserved.
