26526-71-6

Basic information

• Product Name: ethyl 2-cyano-5-methylhexanoate
• CAS NO: 26526-71-6
• Molecular Formula: C₁₀H₁₇NO₂
• Molecular Weight: 183.2475
• Mol File: 26526-71-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 223.1°C at 760 mmHg
• Flash Point: 95.1°C
• Density: 0.958g/cm³
• Vapor Pressure: 0.098mmHg at 25°C
• Refractive Index: 1.435
• CAS DataBase Reference: ethyl 2-cyano-5-methylhexanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-cyano-5-methylhexanoate(26526-71-6)
• EPA Substance Registry System: ethyl 2-cyano-5-methylhexanoate(26526-71-6)

Safety Data

• Hazardous Substances Data: 26526-71-6(Hazardous Substances Data)

Upstream product

• 105-56-6 ethyl 2-cyanoacetate 
• 590-86-3 isovaleraldehyde 
• 107-82-4 i-pentyl bromide 
• 75-03-6 ethyl iodide 
• 18852-51-2 sodium cyanoacetic acid ethyl ester 

Downstream Products

• 399556-78-6 2-ethyl-2-cyano-5-methyl-hexanoic acid ethyl ester 
• 19424-34-1 5-methylhexanenitrile 

Relevant articles and documents

Room Temperature, Reductive Alkylation of Activated Methylene Compounds: Carbon-Carbon Bond Formation Driven by the Rhodium-Catalyzed Water-Gas Shift Reaction

The rhodium-catalyzed water-gas shift reaction has been demonstrated to drive the reductive alkylation of several classes of activated methylene compounds at room temperature. Under catalysis by rhodium trichloride (2-3 mol %), carbon monoxide (10 bar), water (2-50 equiv), and triethylamine (2.5-7 equiv), the scope has been successfully expanded to cover a wide range of alkylating agents, including aliphatic and aromatic aldehydes, as well as cyclic ketones, in moderate to high yields. This method is comparable to, and for certain aspects, surpasses the established reductive alkylation protocols.

Chemoenzymatic synthesis of a series of 4-substituted glutamate analogues and pharmacological characterization at human glutamate transporters subtypes 1-3

A series of nine L-2,4-s;yrc-4-alkylglutamic acid analogues (1a-i) were synthesized in high yield and high enantiomeric excess (>99% ee) from their corresponding 4-substituted ketoglutaric acids (2a-i), using the enzyme aspartate aminotransferase (AAT) from pig heart or E. coli. The synthesized compounds were evaluated as potential ligands for the glutamate transporters EAAT1, EAAT2, and EAAT3 (excitatory amino acid transporter, subtypes 1-3) in the FLIPR membrane potential (FMP) assay. We found a distinct change in the pharmacological profile when the 4-methyl group (compound 1a, an EAAT1 substrate and EAAT2,3 inhibitor) was extended to a 4-ethyl group, compound 1b, as this analogue is an inhibitor at all three subtypes, EAAT1-3. Furthermore, we conclude that both large and bulky hydrophobic substituents in the 4-position of L-2,4-syn Glu are allowed by all three glutamate transporter subtypes EAAT1-3 while maintaining inhibitory activity.