26530-24-5Relevant articles and documents
5-chloro-alkyl isothiazolinone preparation method
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Paragraph 0031-0040, (2020/02/10)
The invention relates to a 5-chloro-alkyl isothiazolinone preparation method, which comprises: (1) adding a transition metal halide and crown ether as catalysts and a substrate dialkyl-3,3-dithiodipropionamide into an organic solvent, introducing chlorine, and carrying out a ring-closure reaction at a reaction temperature of less than 0 DEG C for 1-3 h; (2) introducing a mixed gas of chlorine andan inert gas into the reaction, and controlling the temperature at -10 to 10 DEG C and the reaction time at 1-3 h; and (3) when the proportion of the substrate in the reaction system is less than or equal to 10%, stopping the reaction. According to the invention, the yield of the 5-chloro-alkyl isothiazolinone prepared by the method is remarkably higher than the yield of the polychloroalkyl isothiazolinone reported at present, and the fungus inhibition rate of the 5-chloro-alkyl isothiazolinone is equivalent to the fungus inhibition rate of the mainstream bactericide component 4,5-dichloro-octyl isothiazolinone on the market at present; and the preparation method is widely applied to bactericide and preservative formulas in multiple fields.