265325-01-7

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 67973-49-3 4,7-dihydroxy-8-methyl-2H-1-benzopyran-2-one 
• 501-53-1 benzyl chloroformate 
• 219783-80-9 7-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4-hydroxy-8-methyl-2H-1-benzopyran-2-one 

Downstream Products

• 265325-02-8 7-(tert-butyl-diphenyl-silanyloxy)-4-hydroxy-8-methyl-2-oxo-2H-chromene-3-carboxylic acid benzyl ester 
• 265325-08-4 5-Methyl-1H-pyrrole-2-carboxylic acid (2S,3R,4S,5S,6S)-2-[3-benzyloxycarbonyl-8-methyl-2-oxo-4-(toluene-4-sulfonyloxy)-2H-chromen-7-yloxy]-3-hydroxy-5-methoxy-6-methyl-tetrahydro-pyran-4-yl ester 
• 265325-03-9 7-(tert-butyl-diphenyl-silanyloxy)-8-methyl-2-oxo-4-(toluene-4-sulfonyloxy)-2H-chromene-3-carboxylic acid benzyl ester 
• 265325-05-1 7-hydroxy-8-methyl-2-oxo-4-(toluene-4-sulfonyloxy)-2H-chromene-3-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Tosylates in palladium-catalysed coupling reactions. Application to the synthesis of arylcoumarin inhibitors of gyrase B

The palladium-catalysed coupling reaction between tosylate derivatives and organostannanes has been investigated as a methodology for carbon-carbon bond formation. Aryl substituents have been successfully incorporated even in highly functionalised coumarin structures to afford new analogues of the antibiotic novobiocin. (C) 2000 Elsevier Science Ltd.