2654-06-0

Usage

Uses

Used in Pharmaceutical Industry:
1-(1-HYDROXY-2-METHYLPROPAN-2-YL)-3-PHENYLTHIOUREA is used as a therapeutic agent for its anti-inflammatory and analgesic effects, providing relief from pain and inflammation in various conditions.
Used in Medical Research:
1-(1-HYDROXY-2-METHYLPROPAN-2-YL)-3-PHENYLTHIOUREA is used as a research compound for its potential anti-cancer properties, with ongoing studies aiming to understand its mechanisms of action and potential applications in cancer treatment.
Used in Drug Development:
1-(1-HYDROXY-2-METHYLPROPAN-2-YL)-3-PHENYLTHIOUREA is used as a lead compound in drug development, with its unique structure and properties being explored for the creation of novel pharmaceuticals targeting various medical conditions.

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 124-68-5 2-Amino-2-methyl-1-propanol 

Downstream Products

• 5744-31-0 4,5-dihydro-4,4-dimethyl-N-phenyl-2-thiazolamine 
• 91180-73-3 4,4-dimethyl-4,5-dihydro-N-phenyl-2-oxazolamine 
• 5744-31-0 4,4-dimethyl-N-phenyl-4,5-dihydrothiazol-2-amine 

Relevant academic research and scientific papers

A Bench-Stable Vilsmeier Reagent for in situ Alcohol Activation: Synthetic Application in the Synthesis of 2-Amino-2-Thiazolines

A robust, chemoselective direct condensation/cyclization of thioureas and amino alcohols is described. Employing a bench-stable Vilsmeier reagent, methoxymethylene- N, N -dimethyliminium methyl sulfate, the selective in situ activation of alcohols is achieved with high efficiency and broad functional-group tolerance. The reversible interaction of the Vilsmeier reagent with substrate was key to the success of this activation strategy.

Development of Amino-Oxazoline and Amino-Thiazoline Organic Catalysts for the Ring-Opening Polymerisation of Lactide

The ring-opening polymerisation of lactide by a range of aminooxazoline and amino-thiazoline catalysts is reported. The more electronrich derivatives are demonstrated to be the most highly active and polymerisation is well controlled, as evidenced by the

A selective and convenient method for the synthesis of 2- phenylaminothiazolines

A series of 2-phenylaminothiazolines have been prepared from the corresponding N-(2-hydroxyethyl)-N'-phenylthioureas under mild reaction conditions using either thio-CDI (1,1'-thiocarbonyldiimidazole) or CDI (1,1'-carbonyldiimidazole) to promote the cycli

A convenient method for the synthesis of 2-amino substituted aza-heterocycles from N,N′-disubstituted thioureas using TsCl/NaOH

p-Toluenesulfonyl chloride (TsCl)/NaOH has been introduced as reagent combination for the synthesis of 2-amino-oxa- or 2-amino-thiazolidines from N-(2-hydroxyethyl)-thioureas, but its general application in heterocycle synthesis has not been investigated. In this paper the convenient and efficient synthesis of a variety of 2-amino-substituted 1-aza 3-(aza, oxo or thio) heterocycles of different substitution and ring sizes is described. The application of polymer-supported TsCl facilitates work-up and renders the reaction conditions very suitable for parallel or robot synthesis. Graphical Abstract

One-pot synthesis of 2-phenylaminothiazolines from N-(2-hydroxyethyl)-N'-phenylthioureas

2-Phenylaminothiazolines 3 were synthesized from N-(2-hydroxyethyl)-N'-phenylthioureas 2 by a one-pot reaction using p-toluenesulfonyl chloride (TsCl) and NaOH or Et3N.