26582-86-5Relevant academic research and scientific papers
An efficient, stereocontrolled and versatile synthetic route to bicyclic partially saturated privileged scaffolds
Bond, Andrew D.,Hanby, Abigail R.,King, Thomas A.,Moss, Thomas A.,Sore, Hannah F.,Spring, David R.,Stewart, Hannah L.
supporting information, p. 6818 - 6821 (2020/07/04)
Herein, we describe the development of a simple, high yielding and stereocontrolled strategy for the synthesis of a series of triazolopiperazines and other biologically relevant fused scaffolds from optically active amino acids. This route was applied to the synthesis of 22 scaffolds containing new, previously inaccessible vectors and used to access a novel analogue of ganaplacide.
A new synthesis of chiral oxazolidinones from the amino acid L-serine
Nogueira, Thais C. M.,Pinheiro, Alessandra C.,Kaiser, Carlos R.,Wardell, James L.,Wardell, Solange M. S. V.,De Souza, Marcus V. N.
, p. 626 - 631 (2013/12/04)
Cyclization of the (4S)-PhCH2OCONHCH(CH2OH)CONHN=CH- aryl, obtained in 4 steps from L-serine, on treatment with MeI and potassium carbonate, generates the chiral oxazolidinones, (4S)-N'-[(E)-(phenyl) methylidene]-Nmethyl- 2-oxo-1,3-o
Synthesis and antitumoral evaluation of benzyl (1S)-2-[2-(monosubstituted- benzylidene)hydrazino]-1-(hydroxymethyl)-2-oxoethylcarbamate
Montenegro, Raquel Carvalho,Lotufo, Leticia Veras Costa,De Moraes, Manoel Odorico,Pessoa, Claudia Do O.,Rodrigues, Felipe Augusto Rocha,Pinheiro, Alessandra Campbell,Nogueira, Thais Cristina Mendonca,De Souza, Marcus Vinicius Nora
experimental part, p. 257 - 262 (2012/06/18)
A series of 14 N-acyl-hydrazones L-serine derivatives have been synthesized and evaluated for their in vitro antitumoral activities against four neoplastic cancer cells: HL-60 (leukemia), MDA-MB-435 (melanoma), HCT-8 (colon) and SF-295 (nervous system). F
Combinatorial synthesis of 3,5-Dimethylene substituted 1,2,4-Triazoles
Woodard, Scott S.,Jerome, Kevin D.
, p. 132 - 137 (2012/04/18)
Combinatorial cyclizations of imidates and hydrazides with methylene linked R groups, generated from the corresponding nitriles and carboxylic acids, respectively, provided a large library of 3,5-dimethylene substituted 1,2,4- trizoles. 2011 Bentham Science Publishers Ltd.
