23161-27-5

Upstream product

• 2768-56-1 Z-DL-serine 
• 368-39-8 triethyloxonium fluoroborate 
• 3940-27-0 serine ethyl ester hydrochloride 
• 64-17-5 ethanol 
• 1676-81-9 N-benzyloxycarbonyl-L-serine methyl ester 
• 7087-68-5 N-ethyl-N,N-diisopropylamine 
• 1145-80-8 N-(benzyloxycarbonyl)-L-serine 

Downstream Products

• 4526-93-6 N-(N-benzyloxycarbonyl-L-seryl)-glycine ethyl ester 
• 1139269-96-7 ethyl L-2-[(benzyloxycarbonyl)amino]-3-iodopropanoate 
• 120824-81-9 diethyl benzyloxycarbonyl-γ-carboxy-DL-pyroglutamate 
• 120824-80-8 N-benzyloxycarbonyl-O-p-toluenesulfonyl-DL-serine ethyl ester 
• 26582-86-5 benzyl (1S)-2-hydrazino-1-(hydroxymethyl)-2-oxoethylcarbamate 
• 1055326-46-9 C₁₄H₁₉NO₅ 

Relevant academic research and scientific papers

Combinatorial synthesis of 3,5-Dimethylene substituted 1,2,4-Triazoles

Combinatorial cyclizations of imidates and hydrazides with methylene linked R groups, generated from the corresponding nitriles and carboxylic acids, respectively, provided a large library of 3,5-dimethylene substituted 1,2,4- trizoles. 2011 Bentham Science Publishers Ltd.

Papain-catalyzed esterification of N(α)-protected amino acids and dipeptides with ethanol in different organic systems

The papain-catalyzed esterification of N(α)-protected amino acids and dipeptides with ethanol in mostly hydrophobic organic solvent systems containing low amounts of water has been investigated. The influence of various parameters, such as the amount of added water, reaction time, temperature and pH of added buffer, on the yield of ester was studied first on the model substrate Z-Ala. The optimized reaction conditions were then used for esterification of a series of N(α)-protected amino acids and dipeptides.

PAPAIN-ASSISTED RESOLUTION OF NATURAL AND XENOBIOTIC α-AMINO ACIDS

A new and convenient method for the preparation of pure enantiomers of α-amino acids is described.Industrial papain, catalyzes the synthesis of L-Z-amino acid ethyl esters in ethanolic medium, with good yields.These esters are obtained from DL-Z-amino acids with 100percent optical purity.Unreactive D-Z-amino acids are readily isolated from reaction medium.Physical constants of natural and xenobiotic L-Z-amino acid esters and D-Z-amino acids are described.

L-aminodicarboxylic-(O-cycloalkyl)-L-aminocarboxylate alkyl ester sweeteners

Dipeptides of certain α-amino dicarboxylic acids and etherified hydroxy α-amino-mono-carboxylic acid esters possess a high order of sweetness. These dipeptides have the following formula: STR1 wherein R is alkyl containing 1-3 carbon atoms; R1