26593-47-5Relevant academic research and scientific papers
Cobalt- versus ruthenium-catalyzed Alder-ene reaction for the synthesis of credneramide A and B
Erver, Florian,Hilt, Gerhard
experimental part, p. 5215 - 5219 (2012/07/16)
The first synthesis of the natural products credneramide A and B was accomplished by utilizing Alder-ene reactions between a terminal alkene and an internal alkyne to generate the rather uncommon 1,4-diene substructure of these compounds. Moreover, two different short linear sequences toward these targets are evaluated using either a cobalt-catalyzed Alder-ene reaction of 1-chloropent-1-yne or a ruthenium-catalyzed Alder-ene reaction of 1-trimethylsilyl-1-pentyne with 5-hexenoic acid derivatives in the key step transformation. In addition, saponification of the primary Alder-ene product derived from the cobalt-catalyzed Alder-ene reaction led to credneric acid, the biological precursor of both natural products.
REACTION OF α,α,ω-TRICHLORO- AND α,α,α,ω-TETRACHLOROALKANES WITH ALKALI METAL ACYLATES IN APROTIC SOLVENTS
Kruglova, N. V.
, p. 2530 - 2533 (2007/10/02)
Polychloroalkanes and -alkenes R(CH2)nCl (R=CHCl2CH2, CCl2=CH, n=1,3) in dipolar aprotic solvents - dimethylformamide (DMF), dimethylsulfoxide (DMSO), hexamethylphosphoramide (HMPA) - at 130-150 deg C react selectively at the CH2Cl group with salts of car
PRODUCTION OF 1,1-DICHLORO-1-ALKENES BY THE ACTION OF ALKYLMAGNESIUM HALIDES ON 1,1,1-TRICHLORO-2-PROPENE
Zakharkin, L. I.,Zhigareva, G. G.
, p. 1831 - 1833 (2007/10/02)
The synthesis of 1,1-dichloro-1-alkenes was realized by the reaction of alkylmagnesium halides with 1,1,1-trichloro-2-propene. 2-Methyl-7-octadecyne, which is the main starting compound in the synthesis of Z-7,8-epoxy-2-methyloctadecane (Disparlure - the sex pheromone of Porthetria dispar), was obtained from 1,1-dichloro-1-dodecene.
