265989-49-9 Usage
Uses
Used in Pharmaceutical Industry:
4-Hydroxy Atorvastatin Lactone-d5 is used as a therapeutic agent for the treatment of hypercholesterolemia. It functions by inhibiting HMG-CoA reductase, an enzyme involved in cholesterol synthesis, thereby reducing the levels of LDL-cholesterol and triglycerides in the blood.
Used in Research and Development:
4-Hydroxy Atorvastatin Lactone-d5 is utilized as a research tool in the development of new drugs and therapies targeting hypercholesterolemia and related cardiovascular conditions. Its labeled nature allows for easier tracking and analysis in various experimental setups.
Used in Quality Control and Standardization:
4-Hydroxy Atorvastatin Lactone-d5 is employed in the quality control and standardization of Atorvastatin-containing pharmaceutical products. It serves as a reference material to ensure the accuracy and consistency of drug formulations and their therapeutic effects.
Used in Drug Metabolism Studies:
4-Hydroxy Atorvastatin Lactone-d5 is used in drug metabolism studies to understand the metabolic pathways and pharmacokinetics of Atorvastatin. This information is crucial for optimizing drug dosages, minimizing side effects, and improving patient outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 265989-49-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,5,9,8 and 9 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 265989-49:
(8*2)+(7*6)+(6*5)+(5*9)+(4*8)+(3*9)+(2*4)+(1*9)=209
209 % 10 = 9
So 265989-49-9 is a valid CAS Registry Number.
265989-49-9Relevant academic research and scientific papers
Chen, Bang-Chi,Sundeen, Joseph E.,Guo, Peng,Bednarz, Mark S.,Hangeland, Jon J.,Ahmed, Syed Z.,Jemal, Mohammed
, p. 261 - 270 (2000)
D5-labeled isotopomers of atorvastatin, atorvastatin lactone and its hydroxy metabolites were synthesized as internal standards for use in a LC/MS/MS method developed for the simultaneous quantitative determination of atorvastatin and its hydroxy metabolites in human serum. d5-Atorvastatin and d5-atorvastatin lactone were prepared from d5-aniline whereas their corresponding hydroxy metabolites were synthesized using d5-benzaldehyde.
